PDF(Pubmed)
Abstract：
The use of natural products as alternatives to traditional pharmacological treatments in orthodontics is gaining interest due to their anti-inflammatory, antibacterial, and antioxidant properties. This systematic review synthesizes evidence from clinical trials to evaluate the efficacy of natural products in reducing inflammation and bacterial presence in orthodontic and orthognathic treatment settings. The database search was conducted across PubMed, Scopus, and Embase up to January 2024. The review focused on randomized controlled trials only. The selected studies centered on the anti-inflammatory, antibacterial, and antioxidant effects of natural products, adhering to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines for data extraction. Nine studies, totaling 358 participants, were included. Significant findings demonstrated a reduction in gingival inflammation by over 40% with the use of Aloe vera compared to chlorhexidine. Another study noted a decrease in bleeding on probing by 13.6 points in the treatment group over placebo. Additionally, honey showed a rapid modulation of plaque pH and significantly reduced bacterial counts of Streptococcus mutans. Furthermore, the use of resveratrol emulgel was linked to substantial improvements in gingival health, with a reduction in the gingival index and probing pocket depth. The results indicate that natural products can significantly enhance orthodontic treatment outcomes by reducing inflammation and bacterial levels. These products offer effective alternatives to traditional treatments and show potential for integration into routine orthodontic care protocols. Further research is encouraged to standardize application methods and dosages to maximize clinical benefits and patient satisfaction.
摘要：
在正畸学中使用天然产品作为传统药物治疗的替代品，由于它们的抗炎作用，抗菌，和抗氧化性能。本系统综述综合了临床试验的证据，以评估天然产物在正畸和正颌治疗环境中减少炎症和细菌存在的功效。数据库搜索是在PubMed上进行的，Scopus,和Embase至2024年1月。该综述仅集中于随机对照试验。选定的研究集中在抗炎，抗菌，和天然产物的抗氧化作用，遵守系统评价和荟萃分析（PRISMA）数据提取的首选报告项目。九项研究，共358人,包括在内。重要的发现表明，与氯己定相比，使用库拉索芦荟可将牙龈炎症减少40％以上。另一项研究指出，与安慰剂相比，治疗组的探查出血减少了13.6分。此外,蜂蜜显示出快速调节斑块的pH值，并显着减少了变异链球菌的细菌数量。此外，白藜芦醇乳液的使用与牙龈健康的实质性改善有关，牙龈指数和探查袋深度降低。结果表明，天然产物可以通过减少炎症和细菌水平显着提高正畸治疗效果。这些产品为传统治疗提供了有效的替代方案，并显示出融入常规正畸护理方案的潜力。鼓励进一步研究标准化应用方法和剂量，以最大限度地提高临床效益和患者满意度。
