PDF(Pubmed)
Abstract：
Collagen dietary supplements are becoming increasingly popular as a means to reduce signs of skin ageing. The objective of this three-way, randomised, placebo-controlled, double-blind study was to examine and contrast the effects of dietary supplementation with a daily dose of 5 g hydrolysed collagen with 80 mg of vitamin C (CP product) and their combination with 30 mg of hyaluronic acid (CPHA product) over 16 weeks. Validated methods were utilised for the objective evaluation of skin parameters. In total, 87 subjects (women, 40-65 years) completed the entire trial, distributed across the groups as follows: placebo group (n = 29), CPHA group (n = 28), and CP group (n = 30). The results showed beneficial effects of both test products, with notable enhancements in dermis density, skin texture, and a reduction in the severity of wrinkles. In contrast, the administration of either of the products did not yield any significant impacts on skin elasticity or hydration. Observation of the investigated skin parameters did not show superior effects of the addition of hyaluronic acid (HA) to collagen. Therefore, the ability of supplementation with HA to improve the effects on investigated skin parameters beyond the supplementation of collagen alone cannot be confirmed.
摘要：
胶原蛋白膳食补充剂作为减少皮肤老化迹象的手段正变得越来越受欢迎。这三方的目标，随机化，安慰剂对照,双盲研究旨在研究和对比日剂量5g水解胶原蛋白和80mg维生素C(CP产品)以及它们与30mg透明质酸(CPHA产品)联合使用16周的饮食补充效果.验证的方法用于皮肤参数的客观评估。总的来说,87个科目（妇女，40-65岁）完成了整个审判，各组分布如下：安慰剂组(n=29)，CPHA组（n=28），CP组(n=30)。结果显示两种测试产品的有益效果，真皮密度显著增强，皮肤纹理,减少皱纹的严重程度。相比之下,两种产品的给药对皮肤弹性或水合作用均无明显影响.所研究的皮肤参数的观察未显示出将透明质酸(HA)添加到胶原蛋白中的优异效果。因此,除了单独补充胶原蛋白之外，补充HA改善对所研究皮肤参数的影响的能力无法得到证实。
