PDF(Pubmed)
Abstract：
Carotenoids constitute compounds of significant biological interest due to their multiple biological activities, such as antimicrobial, anticancer, antiadipogenic, antidiabetic, and antioxidant properties. Metabolic syndrome (MetS) comprehends a series of metabolic abnormalities (e.g., hypertension, obesity, and atherogenic dyslipidemia) that can affect children, adolescents, and the elderly. The treatment of MetS involves numerous medications, which, despite their efficacy, pose challenges due to prolonged use, high costs, and various side effects. Carotenoids and their derivatives have been proposed as alternative treatments to MetS because they reduce serum triglyceride concentrations, promote insulin response, inhibit adipogenesis, and downregulate angiotensin-converting enzyme activity. However, carotenoids are notably sensitive to pH, light exposure, and temperature. This review addresses the activity of carotenoids such as lycopene, lutein, fucoxanthin, astaxanthin, crocin, and β-carotene towards MetS. It includes a discussion of sources, extraction methods, and characterization techniques for analyzing carotenoids. Encapsulation approaches are critically reviewed as alternatives to prevent degradation and improve the biological performance of carotenoids. A brief overview of the physiopathology and epidemiology of the diseases, including MetS, is also provided.
摘要：
类胡萝卜素由于其多种生物活性而构成具有重要生物学意义的化合物。如抗菌剂，抗癌，抗脂肪，抗糖尿病药,和抗氧化性能。代谢综合征(MetS)包括一系列代谢异常(例如，高血压,肥胖，和动脉粥样硬化的血脂异常），可以影响儿童，青少年,和老人。MetS的治疗涉及许多药物，which,尽管它们的功效，由于长期使用而带来挑战，高成本,和各种副作用。类胡萝卜素及其衍生物已被提议作为MetS的替代疗法，因为它们降低血清甘油三酯浓度。促进胰岛素反应，抑制脂肪生成，并下调血管紧张素转换酶的活性。然而,类胡萝卜素对pH值特别敏感,曝光,和温度。这篇综述涉及类胡萝卜素的活性，如番茄红素，叶黄素,岩藻黄质,虾青素,crocin,和β-胡萝卜素对MetS。它包括来源的讨论，提取方法，和分析类胡萝卜素的表征技术。封装方法作为防止降解和改善类胡萝卜素生物学性能的替代方法受到严格审查。疾病的病理生理学和流行病学的简要概述，包括MetS,也提供了。
