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Abstract：
A chemical and biological exploration of the European polypore Dentipellis fragilis afforded two previously undescribed natural products (1 and 2), together with three known derivatives (3-5). Chemical structures of the isolated compounds were confirmed through 1D/2D NMR spectroscopic analyses, mass spectrometry, and by comparison with the reported literature. The relative and absolute configurations of 1 were determined according to the ROESY spectrum and time-dependent density functional theory electronic circular dichroism (TDDFT-ECD), respectively. Furthermore, the absolute configuration of dentipellinol (3) was revisited and revealed to be of (R) configuration. All the isolated compounds were assessed for their cytotoxic and antimicrobial activities, with some being revealed to have weak to moderate antimicrobial activity, particularly against Gram-positive bacteria.
摘要：
对欧洲多孔脆弱牙本质的化学和生物探索提供了两种以前未描述的天然产物（1和2），连同三个已知的衍生物(3-5)。通过1D/2DNMR光谱分析证实了分离化合物的化学结构，质谱,并与报道的文献进行比较。根据ROESY光谱和时间依赖性密度泛函理论电子圆二色性（TDDFT-ECD）确定1的相对和绝对构型，分别。此外，重新审视了牙色酚（3）的绝对构型，并显示为（R）构型。评估所有分离的化合物的细胞毒性和抗菌活性，其中一些被发现具有弱到中等的抗菌活性，特别是针对革兰氏阳性细菌。
