PDF(Pubmed)
Abstract：
Tissue imaging is crucial in oral cancer diagnostics. Imaging techniques such as X-ray imaging, magnetic resonance imaging, optical coherence tomography (OCT) and computed tomography (CT) enable the visualization and analysis of tissues, aiding in the detection and diagnosis of cancers. A significant amount of research has been conducted on designing OCT probes for tissue imaging, but most probes are either heavy, bulky and require external mounting or are lightweight but straight. This study addresses these challenges, resulting in a curved lightweight, low-voltage and compact handheld imaging probe for oral soft tissue examination. To the best of our knowledge, this is the first curved handheld OCT probe with its shape optimized for oral applications. This probe features highly compact all-fiber optics with a diameter of 125 μm and utilizes innovative central deflection magnetic actuation for controlled beam scanning. To ensure vertical stability while scanning oral soft tissues, the fiber was secured through multiple narrow slits at the probe\'s distal end. This apparatus was encased in a 3D-printed angular cylinder tube (15 mm outer diameter, 12 mm inner diameter and 160 mm in length, weighing < 20 g). An angle of 115° makes the probe easy to hold and suitable for scanning in space-limited locations. To validate the feasibility of this probe, we conducted assessments on a multi-layered imaging phantom and human tissues, visualizing microstructural features with high contrast.
摘要：
组织成像在口腔癌诊断中至关重要。成像技术，如X射线成像，磁共振成像，光学相干断层扫描（OCT）和计算机断层扫描（CT）使组织的可视化和分析，帮助检测和诊断癌症。已经进行了大量的研究来设计用于组织成像的OCT探头,但是大多数探测器要么很重，笨重，需要外部安装或重量轻，但直。这项研究解决了这些挑战，导致弯曲的轻质，用于口腔软组织检查的低压紧凑型手持式成像探头。据我们所知,这是第一种弯曲的手持式OCT探头，其形状针对口腔应用进行了优化。该探头具有直径为125μm的高度紧凑的全光纤，并采用创新的中央偏转磁致动控制光束扫描。为了确保扫描口腔软组织时的垂直稳定性，光纤通过多个窄缝固定在探头的远端。该设备被包裹在3D打印的角形圆柱管中（外径15毫米，内径12毫米，长度160毫米，称重<20g)。115°的角度使探头易于握持，适合在空间有限的位置进行扫描。为了验证这个探测器的可行性，我们对多层成像模型和人体组织进行了评估，可视化的微观结构特征与高对比度。
