PDF(Pubmed)
Abstract：
Patients with chronic obstructive pulmonary disease (COPD) infected with SARS-CoV-2 indicate a higher risk of severe COVID-19 course, which is defined as the need for hospitalization in the intensive care unit, mechanical ventilation, or death. However, simple tools to stratify the risk in patients with COPD suffering from COVID-19 are lacking. The current study aimed to evaluate the predictive value of the C2HEST score in patients with COPD. A retrospective analysis of medical records from 2184 patients hospitalized with COVID-19 at the University Hospital in Wroclaw from February 2020 to June 2021, which was previously used in earlier studies, assessed outcomes such as mortality during hospitalization, all-cause mortality at 3 and 6 months, non-fatal discharge, as well as adverse clinical incidents. This re-analysis specifically examines the outcomes using a COPD split. In the COPD group, 42 deaths were recorded, including 18 in-hospital deaths. In-hospital mortality rates at 3 and 6 months did not significantly differ among C2HEST strata, nor did their impact on subsequent treatment. However, a notable association between the C2HEST score and prognosis was observed in the non-COPD cohort comprising 2109 patients. The C2HEST score\'s predictive ability is notably lower in COPD patients compared to non-COPD subjects, with COPD itself indicating a high mortality risk. However, C2HEST effectively identifies patients at high risk of cardiac complications during COVID-19, especially in non-COPD cases.
摘要：
感染SARS-CoV-2的慢性阻塞性肺疾病（COPD）患者表明发生严重COVID-19疗程的风险更高，这被定义为需要在重症监护室住院，机械通气,或死亡。然而,缺乏简单的工具来对患有COVID-19的COPD患者进行风险分层。本研究旨在评估C2HEST评分对COPD患者的预测价值。对2020年2月至2021年6月在弗罗茨瓦夫大学医院住院的2184例COVID-19患者的病历进行了回顾性分析，该病历先前已用于早期研究，评估结果，如住院期间的死亡率，3个月和6个月的全因死亡率，非致命性放电,以及不良临床事件。该重新分析使用COPD分割特别检查了结果。在COPD组中，有42人死亡记录,包括18例住院死亡。在C2HEST地层中，3个月和6个月的住院死亡率没有显着差异，对后续治疗也无影响。然而,在包含2109例患者的非COPD队列中,观察到C2HEST评分与预后之间存在显著关联.与非COPD受试者相比，COPD患者的C2HEST评分的预测能力明显较低，COPD本身表明高死亡风险。然而,C2HEST可有效识别COVID-19期间心脏并发症高风险的患者，特别是在非COPD病例中。
