PDF(Pubmed)
Abstract：
Biofilm formation is a serious problem that relatively often causes complications in orthopedic surgery. Biofilm-forming pathogens invade implanted foreign bodies and surrounding tissues. Such a condition, if not limited at the appropriate time, often requires reoperation. This can be partially prevented by selecting an appropriate prosthesis material that prevents the development of biofilm. There are many modern techniques available to detect the formed biofilm. By applying them we can identify and visualize biofilm-forming microorganisms. The most common etiological factors associated with biofilms in orthopedics are: Staphylococcus aureus, coagulase-negative Staphylococci (CoNS), and Enterococcus spp., whereas Gram-negative bacilli and Candida spp. also deserve attention. It seems crucial, for therapeutic success, to eradicate the microorganisms able to form biofilm after the implantation of endoprostheses. Planning the effective targeted antimicrobial treatment of postoperative infections requires accurate identification of the microorganism responsible for the complications of the procedure. The modern microbiological testing techniques described in this article show the diagnostic options that can be followed to enable the implementation of effective treatment.
摘要：
生物膜形成是一个严重的问题，在骨科手术中经常引起并发症。生物膜形成病原体侵入植入的异物和周围组织。这样的条件,如果不限制在适当的时候，经常需要再次手术。这可以通过选择防止生物膜发展的适当假体材料来部分地防止。有许多现代技术可用于检测形成的生物膜。通过应用它们，我们可以识别和可视化生物膜形成微生物。与骨科生物膜相关的最常见的病因是：金黄色葡萄球菌，凝固酶阴性葡萄球菌（CoNS），和肠球菌属。,而革兰氏阴性杆菌和念珠菌。也值得关注。这似乎至关重要，为了治疗成功，根除植入内置假体后能够形成生物膜的微生物。规划术后感染的有效靶向抗微生物治疗需要准确识别导致手术并发症的微生物。本文描述的现代微生物测试技术显示了可以遵循的诊断选项，以实现有效的治疗。
