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Abstract：
Background: Psoriasis is a common inflammatory disease that is often associated with itch and pain. This study aimed to evaluate the clinical characteristics of skin pain among patients with psoriasis. Materials: A total of 106 patients diagnosed with psoriasis were included in the study (34% female; mean age 42.1 ± 13.0 years). Disease severity was assessed using the Psoriasis Area and Severity Index (PASI). Itch severity was evaluated using the numeric rating scale (NRS) and 4-Item Itch Score (4IIS). The intensity of skin pain was measured through the NRS, short-form McGill pain questionnaire (SF-MPQ), visual analog scale (VAS), and Douleur Neuropathique-4 questionnaire (DN4). Results: In the past week, 84.9% of psoriasis patients reported itch, while 50% of them reported skin pain. The average NRS for itch was 4.52 ± 2.88 points, and the 4IIS yielded a mean score of 6.79 ± 4.37 points. In terms of the intensity of cutaneous pain, the mean NRS was 2.42 ± 2.96 points; the SF-MPQ score averaged 4.84 ± 7.51 points; and the VAS score was 1.92 ± 2.65 points. Furthermore, 17% of adult psoriasis patients reported neuropathic pain. In 84.9% of the participants, skin pain was concurrent with areas affected by itch, while 18.9% of patients exhibited cutaneous pain encompassing all itchy areas. The pain NRS demonstrated significant correlations with the SF-MPQ (r = 0.531, p < 0.001), VAS (r = 0.779, p < 0.001), itch NRS (r = 0.551, p < 0.001), and 4IIS (r = 0.569, p < 0.001). No association was found between the pain NRS and PASI or disease duration. Conclusions: Skin pain of mild intensity and itch of moderate intensity are prevalent symptoms in psoriasis patients. Strong correlations between skin pain and itch can be explained by the process of neurogenic inflammation.
摘要：
背景：银屑病是一种常见的炎症性疾病，常伴有瘙痒和疼痛。本研究旨在评估银屑病患者皮肤疼痛的临床特点。材料:总共106名被诊断为牛皮癣的患者被纳入研究(34%为女性;平均年龄42.1±13.0岁)。使用牛皮癣面积和严重程度指数(PASI)评估疾病严重程度。使用数字评定量表（NRS）和4项瘙痒评分（4IIS）评估瘙痒严重程度。通过NRS测量皮肤疼痛的强度，简式麦吉尔疼痛问卷(SF-MPQ)，视觉模拟量表(VAS)，和DouleurNeuropathique-4问卷（DN4）。结果：在过去的一周中，84.9%的银屑病患者报告瘙痒，而50%的人报告皮肤疼痛。瘙痒的平均NRS为4.52±2.88分,4IIS的平均得分为6.79±4.37分。就皮肤疼痛的强度而言，平均NRS为2.42±2.96分;SF-MPQ评分平均为4.84±7.51分;VAS评分为1.92±2.65分.此外，17%的成人银屑病患者报告神经性疼痛。在84.9%的参与者中，皮肤疼痛与受瘙痒影响的区域同时发生，而18.9%的患者表现出涵盖所有瘙痒区域的皮肤疼痛。疼痛NRS与SF-MPQ显著相关(r=0.531,p<0.001),VAS（r=0.779，p<0.001），痒NRS（r=0.551，p<0.001），和4IIS(r=0.569,p<0.001)。疼痛NRS与PASI或疾病持续时间之间未发现关联。结论：轻度皮肤疼痛和中度瘙痒是银屑病患者的常见症状。皮肤疼痛和瘙痒之间的强相关性可以通过神经源性炎症的过程来解释。
