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Abstract：
Background: Human papilloma virus (HPV) infection and the management of its persistence is still a great medical challenge. Recently, scientific evidence has supported the potential therapeutic effects of four combined natural molecules-epigallocatechin gallate (EGCG), folic acid, vitamin B12 and hyaluronic acid (HA)-in counteracting HPV DNA positivity and related cytological lesions. Methods: Each patient of these five clinical cases had persistent HPV positivity in the anogenital site and assumed a dietary supplement based on a combination of 200 mg of EGCG, 50 mg of HA, 1 mg of vitamin B12 and 400 mcg of folic acid (Pervistop®, Farmares s.r.l., Rome, Italy) at a dosage of 1 or 2 caps/day for 6 or 3 months, respectively, depending on clinical history. Results: After treatment, all the patients reported a negative HPV DNA test and improved cytological lesions, thus demonstrating the ability of these combined molecules to counteract both anal and cervical HPV infection and related manifestations. Conclusions: Overall, these data corroborate previous evidence about the effectiveness of such natural molecules in the management of HPV infection and its persistence. Naturally, further studies with a larger population and long-term follow-up will contribute to reinforce the positive effects of this dietary supplement in counteracting HPV infection.
摘要：
背景：人乳头瘤病毒（HPV）感染及其持久性的管理仍然是一个巨大的医学挑战。最近,科学证据支持四种天然分子-表没食子儿茶素没食子酸酯（EGCG）的潜在治疗效果，叶酸,维生素B12和透明质酸（HA）-在对抗HPVDNA阳性和相关的细胞学病变。方法：这5例临床病例中的每位患者在肛门生殖器部位均具有持续的HPV阳性，并根据200mgEGCG的组合进行饮食补充，50毫克的HA，1毫克维生素B12和400微克叶酸（Pervistop®，Farmaress.r.l.,罗马,意大利）的剂量为1或2帽/天，持续6或3个月，分别,取决于临床病史。结果:经过治疗,所有患者均报告HPVDNA检测阴性，细胞学病变改善，从而证明了这些联合分子对抗肛门和宫颈HPV感染及相关表现的能力。结论：总体而言，这些数据证实了先前关于此类天然分子在HPV感染管理中的有效性及其持久性的证据.自然,在更大的人群和长期随访中进行的进一步研究将有助于加强这种膳食补充剂在对抗HPV感染方面的积极作用.
