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Abstract：
Background: Spinal cord compression is a formidable complication of advanced cancer, and clinicians of copious specialities often have to encounter significant complex challenges in terms of diagnosis, management, and prognosis. Metastatic lesions from cancer are a common cause of spinal cord compression, affecting a substantial portion of oncology patients, and only in the US has the percentage risen to 10%. Acute metastasis-correlated spinal cord compression poses a considerable clinical challenge, necessitating timely diagnosis and intervention to prevent neurological deficits. Clinical presentation is often non-specific, emphasizing the importance of thorough evaluation and appropriate differential diagnosis. Diagnostic workup involves various imaging modalities and laboratory studies to confirm the diagnosis and assess the extent of compression. Treatment strategies focus on pain management and preserving spinal cord function without significantly increasing patient life expectancy, while multidisciplinary approaches are often required for optimal outcomes. Prognosis depends on several factors, highlighting the importance of early intervention. We provide an up-to-date overview of acute spinal cord compression in metastases, accentuating the importance of comprehensive management strategies. Objectives: This paper extensively explores the pathophysiology, clinical presentation, diagnostic strategies, treatment modalities, and prognosis associated with spinal cord metastases. Materials and Methods: A systematic literature review was conducted in accordance with the PRISMA guidelines. Conclusions: We aim to help healthcare professionals make informed clinical decisions when treating patients with spinal cord metastases by synthesizing current evidence and clinical insights.
摘要：
背景：脊髓压迫是晚期癌症的一种严重并发症，和临床医生的丰富的专业往往遇到重大的复杂的挑战，在诊断方面，管理,和预后。癌症的转移性病变是脊髓压迫的常见原因，影响了很大一部分肿瘤患者，只有在美国，这一比例上升到10%。急性转移相关的脊髓压迫构成了相当大的临床挑战，需要及时诊断和干预以防止神经功能缺损。临床表现通常是非特异性的，强调全面评估和适当鉴别诊断的重要性。诊断检查涉及各种成像方式和实验室研究，以确认诊断并评估压迫程度。治疗策略侧重于疼痛管理和保留脊髓功能，而不会显着增加患者的预期寿命。而多学科方法往往需要最佳结果。预后取决于几个因素，强调早期干预的重要性。我们提供了急性脊髓压迫转移瘤的最新概述，强调综合管理战略的重要性。目的：本文广泛探讨了病理生理学，临床表现,诊断策略，治疗方式，与脊髓转移相关的预后。材料和方法：根据PRISMA指南进行了系统的文献综述。结论：我们的目标是通过综合目前的证据和临床见解，帮助医疗保健专业人员在治疗脊髓转移患者时做出明智的临床决定。
