PDF(Pubmed)
Abstract：
Background: This study aims to retrospectively investigate the prognostic significance of the tumor microenvironment, with a focus on TILs (tumor-infiltrating lymphocytes), in relation to survival in a large cohort of patients with parotid gland cancer, and it uses the method proposed by the International TILs Working Group in breast cancer. Methods: We included a cohort of consecutive patients with biopsy-proven parotid cancer who underwent surgery between January 2010 and September 2023. A retrospective review of medical records, including surgical, pathological and follow-up reports, was performed. The density of TILs was determined according to the recommendations of the International TILs Working Group for breast cancer. Results: A weak negative correlation (p = 0.3) between TILs and time of survival and a weak positive correlation (p = 0.05) between TILs and months of survival (high TILs were correlated with longer survival in months) were identified. High TILs were weakly negatively, but not statistically significantly p (0.7), correlated with the grading of tumor; this means that high TILs were associated with low-grade tumors. Conclusions: Contrary to previous preliminary reports, this retrospective work found no statistically significant prognostic role of TILs in parotid gland malignancies. This case series represents the largest cohort ever reported in the literature and includes all malignant histological types. Future larger molecular studies may be useful in this regard.
摘要：
背景：本研究旨在回顾性研究肿瘤微环境的预后意义，以TIL（肿瘤浸润淋巴细胞）为重点，与一大群腮腺癌患者的生存率有关，它使用了国际TILs工作组在乳腺癌中提出的方法。方法：我们纳入了2010年1月至2023年9月期间接受手术的经活检证实的腮腺癌连续患者队列。对病历的回顾性审查，包括外科手术,病理和随访报告，已执行。根据乳腺癌国际TILs工作组的建议确定TILs的密度。结果：发现TIL与生存时间之间存在弱负相关（p=0.3），TIL与生存月之间存在弱正相关（p=0.05）（高TIL与更长的生存月相关）。高TIL是弱负的，但没有统计学意义的p(0.7)，与肿瘤分级相关；这意味着高TIL与低度肿瘤相关。结论：与以前的初步报告相反，这项回顾性研究发现,TILs在腮腺恶性肿瘤中的预后作用无统计学意义.该病例系列代表了文献中报道的最大队列，包括所有恶性组织学类型。未来更大的分子研究在这方面可能是有用的。
