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Abstract：
Background/Objectives: Levels of circulating soluble thrombomodulin (sTM), an anticoagulant factor, are associated with the severity and progression of arteriosclerotic diseases. However, the role of elevated sTM levels remains to be clarified in patients on dialysis. As the calcification propensity time T50 is a novel marker of arterial calcification, we aimed to determine the association between sTM and T50 in patients on hemodialysis (HD). Methods: This cross-sectional study included 49 adult patients on maintenance HD. Correlation analysis was performed to test the association between T50 and patient characteristics. Linear regression was used to evaluate the association between T50 and sTM. Results: Partial correlation analysis showed a strong association between T50 and glycated albumin, phosphorous, and sTM levels (partial correlation coefficient: r [partial] = -0.359, p = 0.023; r [partial] = -0.579, p < 0.001; and r [partial] = 0.346, p = 0.029, respectively). Multivariate linear regression analysis revealed that only sTM level was significantly and positively associated with T50 (β = 0.288; t = 2.27; p = 0.029; 95% confidence interval, 0.082-1.403). Conclusions: sTM is independently and positively associated with the propensity time for calcification, suggesting that sTM could be a good marker of arterial calcification progression in patients on HD.
摘要：
背景/目的：循环可溶性血栓调节蛋白（sTM）的水平，一种抗凝血因子,与动脉硬化疾病的严重程度和进展有关。然而,sTM水平升高在透析患者中的作用尚待阐明.由于钙化倾向时间T50是动脉钙化的新标志，我们旨在确定血液透析(HD)患者sTM和T50之间的相关性.方法：这项横断面研究包括49名成人维持性HD患者。进行相关性分析以检验T50与患者特征之间的关联。线性回归用于评估T50和sTM之间的关联。结果:偏相关分析显示T50与糖化白蛋白有很强的相关性,磷,和sTM水平(部分相关系数:r[部分]=-0.359,p=0.023;r[部分]=-0.579,p<0.001;和r[部分]=0.346,p=0.029,分别)。多元线性回归分析显示,只有sTM水平与T50呈显著正相关(β=0.288;t=2.27;p=0.029;95%置信区间,0.082-1.403)。结论:sTM与钙化倾向时间呈独立正相关,提示sTM可能是HD患者动脉钙化进展的良好标志物。
