PDF(Pubmed)
Abstract：
The incidence of obesity and asthma continues to enhance, significantly impacting global public health. Adipose tissue is an organ that secretes hormones and cytokines, causes meta-inflammation, and contributes to the intensification of bronchial hyperreactivity, oxidative stress, and consequently affects the different phenotypes of asthma in obese people. As body weight increases, the risk of severe asthma increases, as well as more frequent exacerbations requiring the use of glucocorticoids and hospitalization, which consequently leads to a deterioration of the quality of life. This review discusses the relationship between obesity and severe asthma, the underlying molecular mechanisms, changes in respiratory function tests in obese people, its impact on the occurrence of comorbidities, and consequently, a different response to conventional asthma treatment. The article also reviews research on possible future therapies for severe asthma. The manuscript is a narrative review of clinical trials in severe asthma and comorbid obesity. The articles were found in the PubMed database using the keywords asthma and obesity. Studies on severe asthma were then selected for inclusion in the article. The sections: \'The classification connected with asthma and obesity\', \'Obesity-related changes in pulmonary functional tests\', and \'Obesity and inflammation\', include studies on subjects without asthma or non-severe asthma, which, according to the authors, familiarize the reader with the pathophysiology of obesity-related asthma.
摘要：
肥胖和哮喘的发病率持续上升,对全球公共卫生产生重大影响。脂肪组织是分泌激素和细胞因子的器官,引起元炎症，并有助于支气管高反应性的加剧，氧化应激，并因此影响肥胖人群哮喘的不同表型。随着体重的增加,严重哮喘的风险增加，以及需要使用糖皮质激素和住院治疗的更频繁的恶化，从而导致生活质量的恶化。本文综述了肥胖与重度哮喘的关系,潜在的分子机制，肥胖人群呼吸功能测试的变化，它对合并症发生的影响，因此，对常规哮喘治疗的不同反应。本文还回顾了未来可能治疗严重哮喘的研究。该手稿是对严重哮喘和肥胖合并症的临床试验的叙述性综述。这些文章是在PubMed数据库中使用关键词哮喘和肥胖找到的。然后选择对严重哮喘的研究纳入本文。这些部分：“与哮喘和肥胖相关的分类”，“肺功能检查中与肥胖相关的变化”，和“肥胖和炎症”，包括对没有哮喘或非严重哮喘的受试者的研究，which,根据作者的说法，让读者熟悉肥胖相关哮喘的病理生理学。
