关键词: aortic valve replacement discordant moderate aortic stenosis iPCSK9 left ventricular disfunction moderate aortic valve stenosis

来  源:   DOI:10.3390/jcm13123478   PDF(Pubmed)

Abstract:
According to current guidelines, only clinical surveillance is recommended for patients with moderate aortic valve stenosis (AS), while aortic valve replacement may be considered in patients undergoing surgery for other indications. Recent studies have shown that moderate AS is associated with a high risk of adverse cardiovascular events, including death, especially in patients with left ventricular dysfunction. In this context, multimodality imaging can help to improve the accuracy of moderate AS diagnosis and to assess left ventricular remodeling response. This review discusses the natural history of this valve disease and the role of multimodality imaging in the diagnostic process, summarizes current evidence on the medical and non-medical management, and highlights ongoing trials on valve replacement.
摘要:
根据目前的指导方针,仅建议对中度主动脉瓣狭窄(AS)患者进行临床监测,而主动脉瓣置换术可以考虑在其他适应症的手术患者。最近的研究表明,中度AS与心血管不良事件的高风险相关。包括死亡,尤其是左心室功能不全的患者。在这种情况下,多模态成像有助于提高中度AS诊断的准确性和评估左心室重构反应。这篇综述讨论了这种瓣膜疾病的自然史以及多模态成像在诊断过程中的作用。总结了当前关于医疗和非医疗管理的证据,并重点介绍了正在进行的瓣膜置换试验。
公众号