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Abstract：
Background/Objectives: Calcinosis cutis is the deposition of insoluble calcium salts, which may cause inflammation, ulceration, pain, and restricted joint mobility. It rarely develops in damaged tissues (dystrophic subtype), most frequently in autoimmune connective tissue diseases (CTDs), but there is very limited data on the prevalence. Also, therapy remains an unsolved issue. In this study, we aimed to collect data on the prevalence of calcinosis in CTD patients to highlight that it is a considerable problem. Methods: A retrospective study was conducted in our department to assess the epidemiology of dystrophic calcinosis in CTDs between January 2003 and January 2024. Results: A total of 839 CTD patients were identified, of whom 56 had calcinosis (6.67%). The mean age of the calcinosis patients at diagnosis of underlying CTD was 41.16 ± 19.47 years. The mean time interval from the onset of calcinosis was 5.96 ± 8.62 years. Systemic sclerosis was the most common CTD complicated by calcinosis (n = 22). Conclusions: Our results are comparable to those reported previously in the literature. Although calcinosis is rare in the overall population, it is a present and unsolved problem in CTD patients. Therefore, further studies are needed on the factors involved in the development and progression of calcinosis as well as its treatment.
摘要：
背景/目的：角质病是不溶性钙盐的沉积，这可能会引起炎症，溃疡,疼痛,限制了关节的机动性。它很少在受损组织（营养不良亚型）中发展，最常见的是自身免疫性结缔组织疾病（CTDs），但是关于患病率的数据非常有限。此外，治疗仍然是一个未解决的问题。在这项研究中,我们旨在收集CTD患者中钙质沉着患病率的数据,以强调这是一个相当大的问题.方法：我科进行了一项回顾性研究，以评估2003年1月至2024年1月间CTD中营养不良性钙质沉着的流行病学。结果：共确定了839例CTD患者，其中56人患有钙质沉着症(6.67%)。诊断为潜在CTD时，钙质沉着患者的平均年龄为41.16±19.47岁。从钙质沉着开始的平均时间间隔为5.96±8.62年。系统性硬化症是最常见的CTD并发钙质沉着症（n=22）。结论：我们的结果与以前文献中报道的结果相当。虽然钙质沉着在总体人群中很少见，这是CTD患者目前尚未解决的问题。因此,钙质沉着的发生和发展的相关因素及其治疗需要进一步研究。
