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Abstract：
Background/Objectives: Acute pancreatitis (AP) is characterized by pancreatic gland inflammation, and its clinical course ranges from mild to severe. Predicting the severity of AP early and reliably is important. In this study, we investigate the potential use of the Controlling Nutritional Status (CONUT) score as a prognostic marker in acute pancreatitis. Methods: We examined 336 patients who had been hospitalized with an AP diagnosis in the internal medicine clinic. The patients included in the study were followed up for 5 years. The study analyzed the specific variables of age, gender, and AP etiology as recorded biochemical parameters for all study participants and calculated the effects of age, sex, Bedside Index of Severity in AP (BISAP), the revised Atlanta classification, and the CONUT score on mortality. Results: When compared with surviving patients, non-surviving patients had higher scores for BISAP, CONUT, and the Atlanta Classification (p ˂ 0.001). In the non-surviving group, hemoglobin, lymphocyte, and albumin levels were significantly lower and creatinine, uric acid, and procalcitonin levels were significantly higher compared to the surviving group (p ˂ 0.001, 0.003, ˂0.001, ˂0.001, 0.005, ˂0.001, respectively). The multivariate analysis showed a significant association of mortality with age, CONUT, and BISAP scores (p ˂ 0.003, 0.001, 0.012 respectively). The CONUT score was separated into two groups based on the median value. The predicted survival time in the group with a CONUT score > 2 (53.8 months) was significantly lower than in the group with a CONUT score ≤ 2 (63.8 months). The cumulative incidence of all-cause mortality was significantly higher in the patients with higher CONUT scores. Conclusions: This study has assigned the CONUT score as an independent risk factor for mortality in AP.
摘要：
背景/目的：急性胰腺炎（AP）的特点是胰腺炎症，其临床病程从轻度到重度不等。早期可靠地预测AP的严重程度很重要。在这项研究中,我们研究了控制营养状况(CONUT)评分作为急性胰腺炎预后指标的潜在用途.方法：我们检查了336例在内科门诊诊断为AP住院的患者。纳入研究的患者随访5年。这项研究分析了年龄的具体变量，性别,和AP病因学作为记录所有研究参与者的生化参数，并计算年龄的影响，性别,AP中的床边严重程度指数（BISAP），修订后的亚特兰大分类，和CONUT死亡率得分。结果：与幸存的患者相比，未存活患者的BISAP得分较高，CONUT,和亚特兰大分类(第0.001页)。在不存活的组中，血红蛋白,淋巴细胞，和白蛋白水平显着降低和肌酐，尿酸,和降钙素原水平显著高于存活组(分别为p<0.001,0.003,<0.001,<0.001,<0.005,<0.001).多变量分析显示死亡率与年龄显著相关，CONUT,和BISAP评分(p分别为0.003、0.001、0.012)。根据中位数将CONUT评分分为两组。CONUT评分>2（53.8个月）组的预测生存时间明显低于CONUT评分≤2（63.8个月）组。在CONUT评分较高的患者中，全因死亡率的累积发生率明显较高。结论：本研究将CONUT评分作为AP患者死亡的独立危险因素。
