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Abstract：
Background: We aimed to characterize the population of consecutive patients undergoing coronary angiography with simultaneous renal artery angiography and assess prognostic factors at a 10 year follow-up. Methods: The KORONEF study was a prospective, single-center, observational, and descriptive study with 492 patients included. We analyzed several baseline demographics, clinical and periprocedural characteristics, and laboratory data, and we assessed the results of coronary angiography and renal artery angiography. Results: The study population consisted of 37.2% women, and the mean age was 64.4 ± 9.9 years (min. 30 years, max. 89 years). Angiography revealed significant renal artery stenosis (RAS) in 35 (7.1%) patients. Among patients with significant RAS (≥50%), we observed more women (57.1% vs. 35.7%, p = 0.011), and patients were older (69.1 ± 10.4 years vs. 64.0 ± 9.7 years, p = 0.005). In the whole population, all-cause death was reported in 29.9% of patients, myocardial infarction (MI) rate-in 11.8%, and stroke-in 4.9%. In the multivariable analysis, independent predictors of death were age 65-75 years (HR 2.88), age > 75 years (HR 8.07), diabetes (HR 1.59), previous MI (HR 1.64), chronic kidney disease (HR 2.22), unstable angina (HR 0.37), and left ventricular ejection fraction > 60% (HR 0.43). Conclusions: Over a 10 year follow-up, the all-cause death rate was 29.9%, showing no statistically significant differences between patients with and without significant RAS.
摘要：
背景：我们旨在表征连续接受冠状动脉造影同时进行肾动脉造影的患者人群，并评估10年随访的预后因素。方法：KORONEF研究是一项前瞻性研究，单中心,观察,包括492例患者的描述性研究。我们分析了几个基线人口统计数据，临床和围手术期特征，和实验室数据，我们评估了冠状动脉造影和肾动脉造影的结果。结果：研究人群由37.2%的女性组成，平均年龄为64.4±9.9岁（min.30年,max.89年）。血管造影显示35例（7.1％）患者有明显的肾动脉狭窄（RAS）。在有显著RAS（≥50%）的患者中，我们观察到更多的女性(57.1%vs.35.7%,p=0.011),患者年龄较大（69.1±10.4岁vs.64.0±9.7年，p=0.005)。在整个人口中，29.9%的患者报告了全因死亡，心肌梗死（MI）发生率为11.8%，和中风-4.9%。在多变量分析中，死亡的独立预测因素是年龄65-75岁（HR2.88），年龄>75岁（HR8.07），糖尿病（HR1.59），上一个MI（HR1.64），慢性肾脏病（HR2.22），不稳定型心绞痛（HR0.37），左心室射血分数>60%(HR0.43)。结论：经过10年的随访，全因死亡率为29.9%，有和没有显著RAS的患者之间没有统计学上的显著差异。
