PDF(Pubmed)
Abstract：
Inflatable penile prosthesis (IPP) surgery is an effective treatment for erectile dysfunction (ED), but infections pose a significant threat to its success. Current guidelines lack antifungal recommendations, despite rising fungal infection rates post-IPP surgery. This review examines epidemiology, risk factors (including diabetes mellitus, immunosuppression, and obesity), and pathogenesis, highlighting the role of biofilm formation in device contamination. Clinical manifestations vary from acute to delayed, with fungal biofilms presenting challenges in diagnosis. Prophylactic strategies, including broad-spectrum antibiotics and antifungals, are crucial, with evidence suggesting a 92% reduction in infections. With fungal infections showing lower salvage rates, management involves culture-guided treatment, irrigation, and oral antibiotics. Future research aims to understand biofilm mechanisms and develop biomaterials to reduce infection rates. Implementing antifungal therapy, along with standard practices like the no-touch technique and antibiotic dips, is crucial in preventing IPP infections.
摘要：
充气阴茎假体(IPP)手术是治疗勃起功能障碍(ED)的有效方法,但是感染对其成功构成重大威胁。目前的指南缺乏抗真菌药的建议，尽管IPP手术后真菌感染率上升。这篇综述探讨了流行病学，危险因素(包括糖尿病，免疫抑制,和肥胖)，和发病机制，强调生物膜形成在设备污染中的作用。临床表现从急性到延迟，真菌生物膜在诊断中提出了挑战。预防性策略,包括广谱抗生素和抗真菌药,是至关重要的,有证据表明感染减少了92%。真菌感染显示较低的抢救率，管理涉及文化指导治疗，灌溉,口服抗生素。未来的研究旨在了解生物膜机制并开发生物材料以降低感染率。实施抗真菌治疗，随着标准的做法，如无接触技术和抗生素浸渍，对预防IPP感染至关重要。
