PDF(Pubmed)
Abstract：
BACKGROUND: Psoriatic arthritis (PsA) is characterized by enthesitis. As persistent inflammation around joints results in bone and cartilage destruction and physical impairment, a detailed assessment of inflammation is essential. We previously reported the difference between clinical assessment (tenderness) and ultrasound (US) assessment (inflammation) of entheses. Herein, we investigated whether clinical or US assessment of joints and entheses can predict the progression of joint destruction in Japanese patients with PsA.
METHODS: Thirty joints and 14 entheses in 47 patients were assessed using US and clinical examination. The US greyscale (GS) and power Doppler (PD) scores at the ultrasonographic synovitis, the US active enthesitis count, and the clinical tender joint/entheses count were assessed. Additionally, the yearly radiographic progression of the Sharp-van der Heijde scoring method for PsA was assessed. Their correlations were investigated.
RESULTS: About half of the patients with PsA experienced joint destruction during a follow-up period of 20.4 months. Progression of joint destruction in patients with PsA only correlated with joint GS and PD scores, reflecting the severity of ultrasonographic synovitis, not with the tender joint/entheses count.
CONCLUSIONS: US examinations are essential for preventing joint destruction and physical impairment in patients with PsA.
METHODS: Thirty joints and 14 entheses in 47 patients were assessed using US and clinical examination. The US greyscale (GS) and power Doppler (PD) scores at the ultrasonographic synovitis, the US active enthesitis count, and the clinical tender joint/entheses count were assessed. Additionally, the yearly radiographic progression of the Sharp-van der Heijde scoring method for PsA was assessed. Their correlations were investigated.
RESULTS: About half of the patients with PsA experienced joint destruction during a follow-up period of 20.4 months. Progression of joint destruction in patients with PsA only correlated with joint GS and PD scores, reflecting the severity of ultrasonographic synovitis, not with the tender joint/entheses count.
CONCLUSIONS: US examinations are essential for preventing joint destruction and physical impairment in patients with PsA.
摘要：
背景：银屑病关节炎（PsA）的特征是附着性炎。由于关节周围持续的炎症导致骨和软骨破坏以及身体损伤，对炎症的详细评估至关重要.我们以前报道了临床评估（压痛）和超声（US）评估（炎症）之间的差异。在这里，我们调查了日本PsA患者的临床或US关节评估是否可以预测关节破坏的进展。
方法：使用US和临床检查评估了47例患者的30个关节和14个关节。超声滑膜炎的US灰度（GS）和能量多普勒（PD）评分，美国活跃的附着体炎计数，并评估了临床招标联合/设计计数。此外,评估了Sharp-vanderHeijdePsA评分方法的年度影像学进展。调查了它们的相关性。
结果：大约一半的PsA患者在20.4个月的随访期间经历了关节破坏。PsA患者关节破坏的进展仅与关节GS和PD评分相关，反映超声滑膜炎的严重程度，不包括投标接头/接头计数。
结论：US检查对于预防PsA患者的关节破坏和身体损伤至关重要。
方法：使用US和临床检查评估了47例患者的30个关节和14个关节。超声滑膜炎的US灰度（GS）和能量多普勒（PD）评分，美国活跃的附着体炎计数，并评估了临床招标联合/设计计数。此外,评估了Sharp-vanderHeijdePsA评分方法的年度影像学进展。调查了它们的相关性。
结果：大约一半的PsA患者在20.4个月的随访期间经历了关节破坏。PsA患者关节破坏的进展仅与关节GS和PD评分相关，反映超声滑膜炎的严重程度，不包括投标接头/接头计数。
结论：US检查对于预防PsA患者的关节破坏和身体损伤至关重要。
