PDF(Pubmed)
Abstract：
Sarcoidosis is a granulomatous disease of unknown etiology that can affect almost any organ. Although the acute form can have spontaneous regression, a certain number of patients can have a chronic form, which leads to an increase in mortality and a decrease in the quality of life. Considering that the risk factors are still unknown, we wanted to compare the characteristics of patients with acute and chronic forms of sarcoidosis in Serbia in order to determine significant differences between them with hopes of contributing to everyday clinical practice. A total of 2380 patients treated in our clinic were enrolled in this study. They were separated into the following two groups: 1126 patients with acute form and 1254 patients with chronic form. They were further compared by gender, smoking status, radiological status, exposition, biomarkers for sarcoidosis, organ involvement, and other comorbidities; the distribution of patients according to regions of Serbia was also noted. Statistical significance was found in radiological findings (p < 0.001), biomarkers (calcium in 24 h urine p < 0.001; chitotriosidase p = 0.001), and the affliction of organs (p < 0.001). The differences noted in this paper could help improve our understanding of this disease.
摘要：
结节病是一种病因不明的肉芽肿性疾病，几乎可以影响任何器官。尽管急性形式可以自发消退，一定数量的患者可以有慢性形式，这导致死亡率增加和生活质量下降。考虑到风险因素仍然未知，我们希望比较塞尔维亚急性和慢性结节病患者的特征,以确定两者之间的显著差异,以期为日常临床实践做出贡献.本研究共招募了2380名在我们诊所接受治疗的患者。将其分离为以下两组：急性形式患者1126例，慢性形式患者1254例。他们进一步按性别进行了比较，吸烟状况,放射学状态，博览会,结节病的生物标志物，器官受累,和其他合并症;还注意到根据塞尔维亚地区的患者分布。放射学发现有统计学意义（p<0.001），生物标志物（24小时尿液中的钙p<0.001；壳三糖苷酶p=0.001），和器官的痛苦（p<0.001）。本文指出的差异可能有助于提高我们对这种疾病的认识。
