PDF(Pubmed)
Abstract：
BACKGROUND: Heart failure, stroke and death are major dangers associated with atrial fibrillation (AF), a common abnormal heart rhythm. Having a gastrointestinal (GI) procedure puts patients at risk for developing AF, especially after large abdominal surgery. Although earlier research has shown a possible connection between postoperative AF and higher mortality, the exact nature of this interaction is yet uncertain.
METHODS: To investigate the relationship between AF and death after GI procedures, this research carried out a thorough meta-analysis and systematic review of randomized controlled studies or clinical trials. Finding relevant randomized controlled trials (RCTs) required a comprehensive search across many databases. Studies involving GI surgery patients with postoperative AF and mortality outcomes were the main focus of the inclusion criteria. We followed PRISMA and Cochrane Collaboration protocols for data extraction and quality assessment, respectively.
RESULTS: After GI surgery, there was no statistically significant difference in mortality between the AF and non-AF groups, according to an analysis of the available trials (p = 0.97). The mortality odds ratio (OR) was 1.03 (95% CI [0.24, 4.41]), suggesting that there was no significant correlation. Nevertheless, there was significant heterogeneity throughout the trials, which calls for careful interpretation.
CONCLUSIONS: Despite the lack of a significant link between AF and death after GI surgery in our study, contradictory data from other research highlight the intricacy of this relationship. Discrepancies may arise from variations in patient demographics, research methodology and procedural problems. These results emphasize the necessity for additional extensive and varied studies to fully clarify the role of AF in postoperative mortality in relation to GI procedures. Comprehending the subtleties of this correlation might enhance future patient outcomes and contribute to evidence-based therapeutic decision making.
METHODS: To investigate the relationship between AF and death after GI procedures, this research carried out a thorough meta-analysis and systematic review of randomized controlled studies or clinical trials. Finding relevant randomized controlled trials (RCTs) required a comprehensive search across many databases. Studies involving GI surgery patients with postoperative AF and mortality outcomes were the main focus of the inclusion criteria. We followed PRISMA and Cochrane Collaboration protocols for data extraction and quality assessment, respectively.
RESULTS: After GI surgery, there was no statistically significant difference in mortality between the AF and non-AF groups, according to an analysis of the available trials (p = 0.97). The mortality odds ratio (OR) was 1.03 (95% CI [0.24, 4.41]), suggesting that there was no significant correlation. Nevertheless, there was significant heterogeneity throughout the trials, which calls for careful interpretation.
CONCLUSIONS: Despite the lack of a significant link between AF and death after GI surgery in our study, contradictory data from other research highlight the intricacy of this relationship. Discrepancies may arise from variations in patient demographics, research methodology and procedural problems. These results emphasize the necessity for additional extensive and varied studies to fully clarify the role of AF in postoperative mortality in relation to GI procedures. Comprehending the subtleties of this correlation might enhance future patient outcomes and contribute to evidence-based therapeutic decision making.
摘要：
背景：心力衰竭，中风和死亡是与心房颤动（AF）相关的主要危险，常见的异常心律.胃肠道（GI）手术会使患者面临发生房颤的风险，尤其是腹部大手术后。尽管早期的研究表明术后房颤与较高的死亡率之间可能存在联系，这种相互作用的确切性质尚不确定。
方法：为了研究房颤与胃肠道手术后死亡之间的关系，这项研究对随机对照研究或临床试验进行了全面的荟萃分析和系统评价.寻找相关的随机对照试验（RCT）需要在许多数据库中进行全面搜索。纳入标准的主要焦点是涉及胃肠道手术患者术后房颤和死亡率的研究。我们遵循PRISMA和Cochrane协作协议进行数据提取和质量评估，分别。
结果：胃肠手术后，房颤组和非房颤组的死亡率差异无统计学意义,根据对现有试验的分析（p=0.97）。死亡率比值比(OR)为1.03(95%CI[0.24,4.41])，表明没有显著的相关性。然而，在整个试验中存在显著的异质性，这需要仔细解释。
结论：尽管在我们的研究中房颤与胃肠道手术后死亡之间缺乏显著的联系，来自其他研究的矛盾数据凸显了这种关系的复杂性。差异可能来自患者人口统计学的变化，研究方法和程序问题。这些结果强调了进一步广泛和多样化研究的必要性，以充分阐明房颤在术后死亡率中与胃肠道手术相关的作用。理解这种相关性的微妙之处可能会增强未来患者的预后，并有助于基于证据的治疗决策。
方法：为了研究房颤与胃肠道手术后死亡之间的关系，这项研究对随机对照研究或临床试验进行了全面的荟萃分析和系统评价.寻找相关的随机对照试验（RCT）需要在许多数据库中进行全面搜索。纳入标准的主要焦点是涉及胃肠道手术患者术后房颤和死亡率的研究。我们遵循PRISMA和Cochrane协作协议进行数据提取和质量评估，分别。
结果：胃肠手术后，房颤组和非房颤组的死亡率差异无统计学意义,根据对现有试验的分析（p=0.97）。死亡率比值比(OR)为1.03(95%CI[0.24,4.41])，表明没有显著的相关性。然而，在整个试验中存在显著的异质性，这需要仔细解释。
结论：尽管在我们的研究中房颤与胃肠道手术后死亡之间缺乏显著的联系，来自其他研究的矛盾数据凸显了这种关系的复杂性。差异可能来自患者人口统计学的变化，研究方法和程序问题。这些结果强调了进一步广泛和多样化研究的必要性，以充分阐明房颤在术后死亡率中与胃肠道手术相关的作用。理解这种相关性的微妙之处可能会增强未来患者的预后，并有助于基于证据的治疗决策。
