PDF(Pubmed)
Abstract：
BACKGROUND: Previous research has indicated a potential correlation between hidradenitis suppurativa (HS) and psoriasis (PSO), two chronic inflammatory dermatological diseases. However, there is a lack of comprehensive evaluations that consider a variety of clinical and demographic factors, and the risk of developing HS in PSO patients remains unclear. Our study aims to examine HS risk over time among PSO patients versus matched controls while considering the influence of confounders to provide insights into the potential link between these two diseases.
METHODS: In this multi-institutional cohort study using the TriNetX database, we matched 202,318 patients with PSO with an equivalent number of individuals without PSO, using propensity score matching. The study period extended from 1 January 2005 to 31 December 2018. We computed hazard ratios and their respective 95% confidence intervals (CIs) to evaluate the probability of HS manifestation over a period of 5 years in patients with PSO in comparison to those without PSO.
RESULTS: PSO patients demonstrated a consistently higher risk of developing HS than matched controls across all analytic models with the hazard ratios (HR) ranging from 1.43 (95% CI 1.30-1.56) to 5.91 (95% CI 2.49-14.04). Stratified analyses showed the increased HS risk was observed in both genders but only significant in those aged 18-64 years. Kaplan-Meier analysis indicated PSO patients had a higher cumulative probability of developing HS over time (HR 1.77, 95% CI 1.49-1.89).
CONCLUSIONS: PSO was associated with increased HS risk, highlighting the importance of considering HS as a potential comorbidity in PSO patients and may have implications for early detection, prevention, and management strategies for both conditions. Shared inflammatory pathways, genetic components, and skin dysbiosis may contribute. Further research should elucidate underlying mechanisms.
METHODS: In this multi-institutional cohort study using the TriNetX database, we matched 202,318 patients with PSO with an equivalent number of individuals without PSO, using propensity score matching. The study period extended from 1 January 2005 to 31 December 2018. We computed hazard ratios and their respective 95% confidence intervals (CIs) to evaluate the probability of HS manifestation over a period of 5 years in patients with PSO in comparison to those without PSO.
RESULTS: PSO patients demonstrated a consistently higher risk of developing HS than matched controls across all analytic models with the hazard ratios (HR) ranging from 1.43 (95% CI 1.30-1.56) to 5.91 (95% CI 2.49-14.04). Stratified analyses showed the increased HS risk was observed in both genders but only significant in those aged 18-64 years. Kaplan-Meier analysis indicated PSO patients had a higher cumulative probability of developing HS over time (HR 1.77, 95% CI 1.49-1.89).
CONCLUSIONS: PSO was associated with increased HS risk, highlighting the importance of considering HS as a potential comorbidity in PSO patients and may have implications for early detection, prevention, and management strategies for both conditions. Shared inflammatory pathways, genetic components, and skin dysbiosis may contribute. Further research should elucidate underlying mechanisms.
摘要：
背景：先前的研究表明化脓性汗腺炎（HS）与银屑病（PSO）之间存在潜在的相关性，两种慢性炎症性皮肤病。然而,缺乏考虑各种临床和人口统计学因素的综合评估，PSO患者发生HS的风险尚不清楚.我们的研究旨在检查PSO患者与匹配对照组之间随时间变化的HS风险，同时考虑混杂因素的影响，以提供对这两种疾病之间潜在联系的见解。
方法：在这项使用TriNetX数据库的多机构队列研究中，我们将202,318例PSO患者与同等数量的无PSO患者进行了匹配，使用倾向得分匹配。研究期从2005年1月1日延长至2018年12月31日。我们计算了风险比及其各自的95％置信区间（CI），以评估与没有PSO的患者相比，PSO患者在5年内出现HS的可能性。
结果：在所有分析模型中，PSO患者发生HS的风险始终高于匹配对照，风险比(HR)范围为1.43(95%CI1.30-1.56)至5.91(95%CI2.49-14.04)。分层分析显示，在两种性别中都观察到HS风险增加，但仅在18-64岁的人群中显着。Kaplan-Meier分析显示，随着时间的推移，PSO患者发生HS的累积概率更高(HR1.77，95%CI1.49-1.89)。
结论：PSO与HS风险增加相关，强调将HS视为PSO患者潜在合并症的重要性，并可能对早期检测产生影响，预防,以及这两种条件的管理策略。共有的炎症途径，遗传成分，和皮肤生态失调可能有贡献。进一步的研究应该阐明潜在的机制。
方法：在这项使用TriNetX数据库的多机构队列研究中，我们将202,318例PSO患者与同等数量的无PSO患者进行了匹配，使用倾向得分匹配。研究期从2005年1月1日延长至2018年12月31日。我们计算了风险比及其各自的95％置信区间（CI），以评估与没有PSO的患者相比，PSO患者在5年内出现HS的可能性。
结果：在所有分析模型中，PSO患者发生HS的风险始终高于匹配对照，风险比(HR)范围为1.43(95%CI1.30-1.56)至5.91(95%CI2.49-14.04)。分层分析显示，在两种性别中都观察到HS风险增加，但仅在18-64岁的人群中显着。Kaplan-Meier分析显示，随着时间的推移，PSO患者发生HS的累积概率更高(HR1.77，95%CI1.49-1.89)。
结论：PSO与HS风险增加相关，强调将HS视为PSO患者潜在合并症的重要性，并可能对早期检测产生影响，预防,以及这两种条件的管理策略。共有的炎症途径，遗传成分，和皮肤生态失调可能有贡献。进一步的研究应该阐明潜在的机制。
