关键词: lung cancer lung metastases metastasectomy pulmonary metastasectomy

来  源:   DOI:10.3390/life14060702   PDF(Pubmed)

Abstract:
Pulmonary metastasectomy has become a well-established procedure for patients with certain types of solid tumors. Patients are usually scheduled for staged lung metastasectomy in case of primary tumor control, the absence of distant non-lung metastases, and when complete resection is achievable. Nodules are removed with precision resection in order to ensure radical resection with minimal margins; this technique permits good oncological results, preserving the surrounding pulmonary parenchyma and causing minimal distortion compared to staplers. When possible, anatomical resections should be avoided since they are not justified by real oncological advantages and, in the majority of cases, sacrifice too much healthy tissue, possibly leading to inoperability in the case of metachronous relapses. Thus, preserving the maximum amount of pulmonary parenchyma is crucial because repeated metastasectomies are possible and frequent, with no theoretical limits to the number of reinterventions. In our multidisciplinary board team, we support the role of pulmonary metastasectomy as a useful curative therapy, with acceptable morbidity and mortality, with indications to be discussed case-by-case.
摘要:
对于某些类型的实体瘤患者,肺转移切除术已成为公认的手术。在原发性肿瘤控制的情况下,患者通常计划进行分期肺转移切除术。没有远处的非肺转移,当完全切除是可以实现的。通过精确切除切除结节,以确保以最小的切缘进行根治性切除;这种技术可以获得良好的肿瘤效果,与缝合器相比,保留周围的肺实质并引起最小的变形。如果可能,应避免解剖切除,因为它们没有真正的肿瘤学优势,在大多数情况下,牺牲了太多的健康组织,在异时复发的情况下可能导致不可操作性。因此,保留最大量的肺实质是至关重要的,因为重复的转移瘤是可能的和频繁的,对再干预的数量没有理论上的限制。在我们的多学科董事会团队中,我们支持肺转移瘤切除术作为一种有用的治疗方法的作用,具有可接受的发病率和死亡率,有迹象需要逐案讨论。
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