PDF(Pubmed)
Abstract：
This study investigates the correlation between COVID-19 and avascular necrosis of the femoral head, considering the potential contribution of medication-induced effects. This research spans the period from August 2022 to January 2024 and includes 32 patients diagnosed with avascular necrosis. While steroid usage, particularly in high doses, is known to predispose individuals to this condition, this study aims to discern if COVID-19 itself plays a role beyond the influence of medication. Notably, COVID-19 is associated with disturbances in the coagulation system, potentially leading to thromboembolic complications. Of the patients, six did not have COVID-19, while seven had the virus but did not receive steroid treatment. However, 19 patients with COVID-19 exhibited severe pulmonary involvement and were administered both high-dose steroids and antiviral medication. Among the observed patients, 14 were female and 18 were male. Notably, three patients presented bilateral necrosis, all of whom had COVID-19 and significant pulmonary involvement. Diagnostic assessments included frontal and profile X-rays, as well as MRI scans for all patients.
摘要：
本研究探讨COVID-19与股骨头缺血性坏死的相关性,考虑药物诱导效应的潜在贡献。这项研究涵盖了2022年8月至2024年1月，包括32例诊断为缺血性坏死的患者。在使用类固醇时，特别是在高剂量下，众所周知，个人容易患上这种疾病，这项研究旨在辨别COVID-19本身是否发挥了药物影响之外的作用。值得注意的是,COVID-19与凝血系统紊乱有关，可能导致血栓栓塞并发症。在患者中，6人没有感染COVID-19，7人感染了病毒，但没有接受类固醇治疗。然而,19例COVID-19患者表现出严重的肺部受累，并接受了大剂量类固醇和抗病毒药物治疗。在观察到的患者中，女性14人，男性18人。值得注意的是,3例患者出现双侧坏死，所有患者均有COVID-19和明显的肺部受累。诊断评估包括正面和轮廓X射线，以及所有患者的MRI扫描。
