PDF(Pubmed)
Abstract：
Background: Contrast-induced nephropathy (CIN) is one of the most important complications after invasive cardiovascular procedures. Considering the pivotal role of inflammation in CIN development, the use of peripheral blood-based indexes may be an easily available biomarker to predict CIN risk. Therefore, in the present study, we evaluated the association between the pan-immune-inflammation value (PIV) and the risk of CIN. Patients and Methods: A total of 1343 patients undergoing coronary angiography (CAG) were included. The PIV was calculated with the following equation: (neutrophil count × platelet count × monocyte count)/lymphocyte count. Multivariable regression analyses were used to determine the association between clinical and laboratory parameters and CIN development. Results: The median age of the cohort was 58 (IQR 50-67), and 48.2% of the patients were female. CIN developed in 202 patients (15%) in follow-up. In multivariate analyses, older age (OR: 1.015, 95% CI: 1.002-1.028, p = 0.020) and higher PIV levels (OR: 1.016, 95% CI: 1.004-1.028, p = 0.008) were associated with a higher CIN risk, while the use of antiplatelet agents was associated with a lower risk of CIN (OR: 0.670, 95% CI: 0.475-0.945, p = 0.022). Conclusions: We demonstrated that the risk of CIN was significantly higher in patients with higher PIV and older patients in a large cohort of patients undergoing CAG for stable ischemic heart disease. If supported with prospective evidence, PIV levels could be used as a minimally invasive reflector of CIN.
摘要：
背景：造影剂肾病（CIN）是侵入性心血管手术后最重要的并发症之一。考虑到炎症在CIN发育中的关键作用，使用基于外周血的指标可能是预测CIN风险的一个容易获得的生物标志物.因此,在本研究中，我们评估了泛免疫炎症值（PIV）与CI风险之间的关联。患者和方法：共纳入1343例接受冠状动脉造影（CAG）的患者。用以下等式计算PIV:(中性粒细胞计数×血小板计数×单核细胞计数)/淋巴细胞计数。多变量回归分析用于确定临床和实验室参数与CIN发展之间的关联。结果：该队列的中位年龄为58岁（IQR50-67），48.2%的患者为女性。在随访中，202例患者(15%)出现CIN。在多变量分析中，年龄较大（OR：1.015，95％CI：1.002-1.028，p=0.020）和较高的PIV水平（OR：1.016，95％CI：1.004-1.028，p=0.008）与较高的CIN风险相关，而使用抗血小板药物与低CIN风险相关(OR:0.670,95%CI:0.475-0.945,p=0.022).结论：我们证明，在接受稳定性缺血性心脏病CAG的大型队列患者中，PIV较高的患者和年龄较大的患者中，CIN的风险明显更高。如果有潜在证据支持，PIV水平可以用作CIN的微创反射器。
