PDF(Pubmed)
Abstract：
Hepatocellular carcinoma (HCC) stands as a significant contributor to cancer-related mortality globally. While the acute and often fatal manifestations of locally advanced HCC primarily present within the abdomen, it is crucial to recognize that the respiratory and circulatory systems can also fall victim due to the liver\'s unique anatomical position within the body. Here, we present the case of a 63-year-old male recently diagnosed with locally advanced HCC with vascular invasion. Shortly after receiving target therapy and focal radiotherapy, the patient developed repeated secondary infections and a persistent diaphragmatic defect. As the necrotic tissue invaded the pleural space, subsequent tumor-to-bronchial and tumor-to-cardiac fistulas emerged, resulting in an abnormal connection between the respiratory and cardiovascular systems, leading to massive air emboli in circulation. This report highlights the risk of supradiaphragmatic complications in HCC patients with post-treatment secondary infections, particularly in patients predisposed to developing diaphragmatic defects.
摘要：
肝细胞癌（HCC）是全球癌症相关死亡率的重要贡献者。虽然局部晚期HCC的急性和通常致命的表现主要存在于腹部内，至关重要的是要认识到，由于肝脏在体内独特的解剖位置，呼吸和循环系统也可能成为受害者。这里,我们介绍了一例63岁男性最近诊断为局部晚期HCC伴血管侵犯的病例.在接受靶向治疗和局灶性放疗后不久，患者出现反复继发感染和持续性膈缺损.坏死组织侵入胸膜腔,随后出现了肿瘤到支气管和肿瘤到心脏的瘘，导致呼吸系统和心血管系统之间的异常连接，导致循环中大量的空气栓塞。本报告强调了HCC患者治疗后继发感染的膈肌并发症的风险，特别是倾向于发展为膈肌缺陷的患者。
