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Abstract：
The prevalence of skin aging and the request for effective treatments have driven dermatological research towards natural solutions. This study investigates the anti-aging efficacy of two bioactive natural polyphenols, Oleocanthal and Oleacein, in a skincare formulation. A single-blind, randomized clinical trial involved 70 participants, using a comprehensive exclusion criterion to ensure participant safety and study integrity. Participants applied the Oleocanthal and Oleacein 1% serum formulation twice daily for 30 days. The efficacy was objectively assessed using the VISIA® Skin Analysis System at baseline, after 15 days, and after 30 days. Results indicated significant wrinkle reduction in most groups. For women aged 45-79 years, the mean change was -33.91% (95% CI: -46.75% to -21.07%). For men aged 20-44 years, it was -51.93% (95% CI: -76.54% to -27.33%), and for men aged 45-79 years, it was -46.56% (95% CI: -58.32% to -34.81%). For women aged 20-44 years, the change was -25.68% (95% CI: -63.91% to 12.54%), not statistically significant. These findings highlight the potential of EVOO-derived polyphenols in anti-aging skincare, particularly for older adults. This research paves the way for further exploration into natural compounds in dermatology, particularly for aging skin management.
摘要：
皮肤老化的流行和对有效治疗的要求已将皮肤病学研究推向自然解决方案。本研究调查了两种生物活性天然多酚的抗衰老功效，Oleocanthal和Oleacein，在护肤配方中。一个单盲,随机临床试验涉及70名参与者，使用全面的排除标准来确保参与者的安全和研究的完整性。参与者每天两次施用Oleocanthal和Oleacein1%血清制剂，持续30天。使用VISIA®皮肤分析系统在基线时客观评估疗效，15天后,30天后。结果表明，大多数组的皱纹明显减少。对于45-79岁的女性，平均变化为-33.91%(95%CI:-46.75%至-21.07%)。对于20-44岁的男性来说，为-51.93%（95%CI：-76.54%至-27.33%），对于45-79岁的男性，为-46.56%（95%CI：-58.32%至-34.81%）。对于20-44岁的女性来说，变化为-25.68%（95%CI：-63.91%至12.54%），没有统计学意义。这些发现凸显了EVOO衍生的多酚在抗衰老护肤品中的潜力，特别是对于老年人。这项研究为进一步探索皮肤病学中的天然化合物铺平了道路。特别是老化的皮肤管理。
