PDF(Pubmed)
Abstract：
Background and Objectives: The aim of the present work was to compare the characteristics of delta and omicron variants of COVID-19 infection in pregnant women, the association of infection with comorbidity, clinical manifestation of the disease, type of delivery, and pregnancy outcome. Material and Methods: The study was designed as an observational, retrospective study of a single center. The analysis included the cohort of women who had SARS-CoV-2 infection during pregnancy and/or childbirth in the period from 1 March 2020 to 30 June 2023. Results: Out of a total of 675 pregnant women with SARS-CoV-2 infection, 130 gave birth with the delta and 253 with the omicron variant. In our retrospective analysis, pregnant women with both SARS-CoV-2 variants had a mild clinical history in most cases. In the omicron period, a significantly lower incidence of pregnancy loss (p < 0.01) and premature birth (p = 0.62) admission of mothers and newborns to the intensive care unit (p < 0.05) was recorded. Conclusions: In our retrospective analysis, pregnant women with COVID-19 infection generally exhibited a milder clinical manifestation with both variants (delta and omicron) of the viral infection. During the delta-dominant period, ten percent of affected pregnant women experienced a severe clinical history. However, during the omicron-dominant period infection, a significantly lower incidence of complications, pregnancy loss, preterm delivery, and admission of mothers and neonates to the intensive care unit was recorded. This can be partly explained by the greater presence of pregnant women with natural or induced vaccine immunity.
摘要：
背景和目的：本工作的目的是比较孕妇感染COVID-19的δ和omicron变体的特征，感染与共病的关联，该疾病的临床表现，交货类型,和妊娠结局。材料和方法：本研究被设计为观察性的，单中心回顾性研究。该分析包括2020年3月1日至2023年6月30日期间在怀孕和/或分娩期间感染SARS-CoV-2的妇女队列。结果:675例感染SARS-CoV-2的孕妇中,130生了三角洲，253生了omicron变体。在我们的回顾性分析中，在大多数病例中,两种SARS-CoV-2变异的孕妇均有轻微的临床病史.在omicron时期，母亲和新生儿入住重症监护病房(p<0.05)的妊娠丢失(p<0.01)和早产(p=0.62)发生率显著降低.结论：在我们的回顾性分析中，患有COVID-19感染的孕妇通常表现出轻度的临床表现，具有病毒感染的两种变体（δ和omicron）。在三角洲主导时期，10%的孕妇有严重的临床病史.然而,在omicron优势期感染期间，并发症发生率明显降低，怀孕失败,早产,并记录了母亲和新生儿进入重症监护病房的情况。这可以部分解释为具有天然或诱导的疫苗免疫的孕妇的更多存在。
