PDF(Pubmed)
Abstract：
Background and Objective: Understanding whether cranial nerve palsy (CNP) acts as an independent risk factor for kidney cancer could have important implications for patient care, early detection, and potentially the development of preventive strategies for this type of cancer in individuals with CNP. This study aimed to examine the risk of kidney cancer following the onset of ocular motor CNP and assess whether CNP could be considered an independent risk factor for kidney cancer. Materials and Methods: A population-based cohort study was conducted using data from the National Sample Cohort (NSC) database of Korea\'s National Health Insurance Service which was collected from 2010 to 2017. Follow-up was until kidney cancer development, death, or 31 December 2018. Cox proportional hazard regression analysis was performed to determine hazard ratios (HRs) for kidney cancer according to CNP status. Participants aged 20 years or more diagnosed with CNP from 2010 to 2017 were included. Exclusions comprised individuals with specific pre-existing conditions, inability to match a control group, and missing data, among others. CNP patients were age-sex matched in a 1:5 ratio with control cases. The primary outcome was incidence of kidney cancer during the follow-up period. Results: This study comprised 118,686 participants: 19,781 in the CNP group, and 98,905 in the control group. Compared to the control group, participants with CNP had a higher risk of kidney cancer (adjusted HR in model 4, 1.599 [95% CI, 1.116-2.29]). After a 3-year lag period, the CNP group had a significantly higher risk (adjusted HR in model 4, 1.987 [95% CI, 1.252-3.154]). Conclusions: Ocular motor CNP may be an independent risk factor for kidney cancer, as indicated by a higher incidence of kidney cancer in CNP patients. Further research is needed to elucidate the underlying mechanisms and explore potential preventive measures for kidney cancer in patients with ocular motor CNP.
摘要：
背景和目的：了解颅神经麻痹（CNP）是否作为肾癌的独立危险因素，对患者的护理具有重要意义。早期发现,并有可能在CNP患者中开发针对此类癌症的预防策略。这项研究旨在检查眼运动CNP发作后肾癌的风险，并评估CNP是否可以被认为是肾癌的独立危险因素。材料和方法：一项基于人群的队列研究使用韩国国家健康保险服务国家样本队列（NSC）数据库的数据进行，该数据库收集于2010年至2017年。随访直到肾癌发展，死亡,或2018年12月31日。进行Cox比例风险回归分析以根据CNP状态确定肾癌的风险比（HRs）。纳入2010年至2017年诊断为CNP的20岁或以上的参与者。排除包括具有特定预先存在条件的个人，无法匹配对照组，缺少数据，在其他人中。CNP患者与对照病例的年龄-性别匹配比例为1:5。主要结果是随访期间肾癌的发生率。结果：这项研究包括118,686名参与者：CNP组19,781名，对照组为98,905。与对照组相比,患有CNP的参与者患肾癌的风险较高(模型4的校正HR,1.599[95%CI,1.116~2.29]).经过3年的滞后期，CNP组的风险显著较高(模型4的校正HR,1.987[95%CI,1.252-3.154]).结论:眼动CNP可能是肾癌的独立危险因素。CNP患者肾癌发病率较高。需要进一步的研究来阐明眼部运动CNP患者肾癌的潜在机制并探索潜在的预防措施。
