PDF(Pubmed)
Abstract：
Ciguatera is a foodborne disease caused by ciguatoxins (CTXs), produced by dinoflagellates (genera Gambierdiscus and Fukuyoa), which bioaccumulate in fish through the food web, causing poisoning in humans. Currently, the physiological mechanisms of the species with the highest amount of toxins in their adult stage of life that are capable of causing these poisonings are poorly understood. Dusky grouper (Epinephelus marginatus) is a relevant fishing species and is part of the CTX food chain in the Canary Islands. This study developed an experimental model of dietary exposure featuring adult dusky groupers with two diets of tissue naturally contaminated with CTXs (amberjack and moray eel flesh) with two different potential toxicities; both groups were studied at different stages of exposure (4, 6, 10, 12, and 18 weeks). The results showed that this species did not show changes in its behavior due to the provided feeding, but the changes were recorded in biochemical parameters (mainly lipid and hepatic metabolism) that may respond to liver damage and alterations in the homeostasis of the fish; more research is needed to understand histopathological and cytotoxic changes.
摘要：
Ciguatera是由雪茄毒素（CTX）引起的食源性疾病，由鞭毛藻（冈比亚属和福约属）产生，通过食物网在鱼中生物积累，导致人类中毒。目前,在其成年阶段能够引起这些中毒的毒素含量最高的物种的生理机制知之甚少。昏暗的石斑鱼（Epinephelusmarginatus）是一种相关的捕捞物种，是加那利群岛CTX食物链的一部分。这项研究开发了一种饮食暴露的实验模型，该模型以成年暗色石斑鱼为特征，其中两种饮食被CTX（amberjack和moray鳗鱼肉）自然污染，具有两种不同的潜在毒性；两组均在暴露的不同阶段（4、6、10、12和18周）进行了研究。结果表明，由于提供的摄食，该物种的行为没有发生变化，但是这些变化记录在生化参数（主要是脂质和肝脏代谢）中，这些参数可能对肝脏损伤和鱼类稳态的改变产生反应；需要更多的研究来了解组织病理学和细胞毒性变化。
