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Abstract：
BACKGROUND: Ultrasound serves as a valuable tool for the early detection of fetal bowel dilatation, yet the correlation between fetal bowel dilatation and gastrointestinal malformations remains to be further investigated. This study aims to explore the relationship by conducting a follow-up and analysis of fetuses with bowel dilation.
METHODS: A retrospective analysis was conducted on 113 fetuses with bowel dilatation at our center from July 2014 to December 2019. The location and degree of bowel dilatation were analyzed. ROC curves were constructed based on the diameter of the bowel and its ratio to fetal gestational age.
RESULTS: In total, 40 of 41 cases (97.6%) with upper gastrointestinal dilatation (double-bubble sign) and 46 of 72 cases (63.9%) with lower gastrointestinal dilatation were diagnosed with gastrointestinal malformations postnatally. The AUC of the dilatation diameter was 0.854 with a cutoff value of 18.05 mm in patients with lower gastrointestinal dilatation. The ratio of the diameter to gestational age (D/GA) showed a higher AUC of 0.906 with a cutoff value of 0.4931.
CONCLUSIONS: The presence of the double-bubble sign in fetuses indicates a close association with duodenal obstruction. The risk of gastrointestinal malformations increases when the bowel diameter exceeds 18.05 mm, particularly when the D/GA surpasses 0.4931.
METHODS: A retrospective analysis was conducted on 113 fetuses with bowel dilatation at our center from July 2014 to December 2019. The location and degree of bowel dilatation were analyzed. ROC curves were constructed based on the diameter of the bowel and its ratio to fetal gestational age.
RESULTS: In total, 40 of 41 cases (97.6%) with upper gastrointestinal dilatation (double-bubble sign) and 46 of 72 cases (63.9%) with lower gastrointestinal dilatation were diagnosed with gastrointestinal malformations postnatally. The AUC of the dilatation diameter was 0.854 with a cutoff value of 18.05 mm in patients with lower gastrointestinal dilatation. The ratio of the diameter to gestational age (D/GA) showed a higher AUC of 0.906 with a cutoff value of 0.4931.
CONCLUSIONS: The presence of the double-bubble sign in fetuses indicates a close association with duodenal obstruction. The risk of gastrointestinal malformations increases when the bowel diameter exceeds 18.05 mm, particularly when the D/GA surpasses 0.4931.
摘要：
背景：超声是早期发现胎儿肠扩张的有价值的工具，然而，胎儿肠扩张与胃肠道畸形之间的相关性仍有待进一步研究。本研究旨在通过对胎儿肠扩张的随访和分析来探讨两者之间的关系。
方法：回顾性分析2014年7月至2019年12月在我们中心进行的113例肠道扩张的胎儿。分析肠扩张的部位和程度。根据肠直径及其与胎儿胎龄的比率构建ROC曲线。
结果：总计，41例中40例(97.6%)上消化道扩张(双泡征)和72例中46例(63.9%)下消化道扩张后诊断为消化道畸形。下消化道扩张患者的扩张直径的AUC为0.854，截止值为18.05mm。直径与胎龄之比(D/GA)显示出较高的AUC为0.906,截断值为0.4931。
结论：胎儿双泡征的存在表明与十二指肠梗阻密切相关。当肠直径超过18.05mm时，胃肠道畸形的风险增加，特别是当D/GA超过0.4931时。
方法：回顾性分析2014年7月至2019年12月在我们中心进行的113例肠道扩张的胎儿。分析肠扩张的部位和程度。根据肠直径及其与胎儿胎龄的比率构建ROC曲线。
结果：总计，41例中40例(97.6%)上消化道扩张(双泡征)和72例中46例(63.9%)下消化道扩张后诊断为消化道畸形。下消化道扩张患者的扩张直径的AUC为0.854，截止值为18.05mm。直径与胎龄之比(D/GA)显示出较高的AUC为0.906,截断值为0.4931。
结论：胎儿双泡征的存在表明与十二指肠梗阻密切相关。当肠直径超过18.05mm时，胃肠道畸形的风险增加，特别是当D/GA超过0.4931时。
