PDF(Pubmed)
Abstract：
The human body comprises numerous organs and tissues operating in synchrony, it facilitates metabolism, circulation, and overall organismal function. Consequently, the well-being of our organs and tissues significantly influences our overall health. In recent years, research on the protective effects of artesunate (AS) on various organ functions, including the heart, liver, brain, lungs, kidneys, gastrointestinal tract, bones, and others has witnessed significant advancements. Findings from in vivo and in vitro studies suggest that AS may emerge as a newfound guardian against organ damage. Its protective mechanisms primarily entail the inhibition of inflammatory factors and affect anti-fibrotic, anti-aging, immune-enhancing, modulation of stem cells, apoptosis, metabolic homeostasis, and autophagy properties. Moreover, AS is attracting a high level of interest because of its obvious antioxidant activities, including the activation of Nrf2 and HO-1 signaling pathways, inhibiting the release of reactive oxygen species, and interfering with the expression of genes and proteins associated with oxidative stress. This review comprehensively outlines the recent strides made by AS in alleviating organismal injuries stemming from various causes and protecting organs, aiming to serve as a reference for further in-depth research and utilization of AS.
摘要：
人体包括许多同步运行的器官和组织，它促进新陈代谢，流通,和整体组织功能。因此,我们的器官和组织的健康会显著影响我们的整体健康。近年来,青蒿琥酯（AS）对各种器官功能的保护作用的研究，包括心脏,肝脏,大脑,肺,肾脏，胃肠道,骨头,其他人见证了重大进步。体内和体外研究的结果表明，AS可能会成为新发现的针对器官损伤的监护人。其保护机制主要包括抑制炎症因子和影响抗纤维化,抗衰老,免疫增强，干细胞的调制，凋亡，代谢稳态，和自噬特性。此外，AS由于其明显的抗氧化活性而引起了人们的高度兴趣，包括Nrf2和HO-1信号通路的激活，抑制活性氧的释放，并干扰与氧化应激相关的基因和蛋白质的表达。这篇综述全面概述了AS在减轻各种原因引起的机体损伤和保护器官方面最近取得的进展。旨在为进一步深入研究和利用AS提供参考。
