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Abstract：
Ischemic stroke is a leading cause of mortality and disability. The relationships of heart rate variability (HRV) and stroke-related factors with mortality and functional outcome are complex and not fully understood. Understanding these relationships is crucial for providing better insights regarding ischemic stroke prognosis. The objective of this study is to examine the relationship between HRV, neurological function, and clinical factors with mortality and 3-month behavioral functional outcome in ischemic stroke. We prospectively collected the HRV data and monitored the behavioral functional outcome of patients with ischemic stroke. The behavioral functional outcome was represented by a modified Rankin Scale (mRS) score. This study population consisted of 58 ischemic stroke patients (56.9% male; mean age 70) with favorable (mRS score ≤ 2) and unfavorable (mRS score ≥ 3) outcome. The analysis indicated that the median of the mean RR interval (RR mean) showed no statistical difference between mortality groups. Conversely, the median of the RR mean had significant association with unfavorable outcome (OR = 0.989, p = 0.007). Lower hemoglobin levels had significant association with unfavorable outcome (OR = 0.411, p = 0.010). Higher National Institute of Health Stroke Scale (NIHSS) score at admission had significant association with unfavorable outcome (OR = 1.396, p = 0.002). In contrast, age, stroke history, NIHSS score at admission, and hemoglobin showed no significant association with mortality in ischemic stroke. These results imply that HRV, as indicated by the median of RR mean, alongside specific clinical factors and neurological function at admission (measured by NIHSS score), may serve as potential prognostic indicators for 3-month behavioral functional outcome in ischemic stroke.
摘要：
缺血性中风是导致死亡和残疾的主要原因。心率变异性（HRV）和卒中相关因素与死亡率和功能结局的关系很复杂，尚未完全了解。了解这些关系对于提供有关缺血性卒中预后的更好见解至关重要。本研究的目的是检验HRV，神经功能,与缺血性卒中死亡率和3个月行为功能结局相关的临床因素。我们前瞻性收集了HRV数据，并监测了缺血性卒中患者的行为功能结局。行为功能结果由改良的Rankin量表(mRS)评分表示。本研究人群包括58例缺血性卒中患者（男性占56.9％；平均年龄70岁），预后良好（mRS评分≤2）和不良（mRS评分≥3）。分析表明，平均RR间期（RRmean）的中位数在死亡组之间没有统计学差异。相反，RR平均值的中位数与不良结局显著相关(OR=0.989,p=0.007).较低的血红蛋白水平与不良结局显著相关(OR=0.411,p=0.010)。入院时美国国立卫生研究院卒中量表（NIHSS）评分较高，与不良结局有显著关联（OR=1.396，p=0.002）。相比之下,年龄,中风史,入院时NIHSS成绩,血红蛋白与缺血性卒中死亡率无显著相关性.这些结果表明，HRV，如RR平均值的中位数所示，除了特定的临床因素和入院时的神经功能（通过NIHSS评分衡量），可作为缺血性卒中3个月行为功能结局的潜在预后指标。
