PDF(Pubmed)
Abstract：
The emergence of 7T clinical MRI technology has sparked our interest in its ability to discern the complex structures of the hand. Our primary objective was to assess the sensory and motor nerve structures of the hand, specifically nerves and Pacinian corpuscles, with the dual purpose of aiding diagnostic endeavors and supporting reconstructive surgical procedures. Ethical approval was obtained to carry out 7T MRI scans on a cohort of volunteers. Four volunteers assumed a prone position, with their hands (N = 8) positioned in a \"superman\" posture. To immobilize and maintain the hand in a strictly horizontal position, it was affixed to a plastic plate. Passive B0 shimming was implemented. Once high-resolution 3D images had been acquired using a multi-transmit head coil, advanced post-processing techniques were used to meticulously delineate the nerve fiber networks and mechanoreceptors. Across all participants, digital nerves were consistently located on the phalanges area, on average, between 2.5 and 3.5 mm beneath the skin, except within flexion folds where the nerve was approximately 1.8 mm from the surface. On the phalanges area, the mean distance from digital nerves to joints was approximately 1.5 mm. The nerves of the fingers were closer to the bone than to the surface of the skin. Furthermore, Pacinian corpuscles exhibited a notable clustering primarily within the metacarpal zone, situated on the palmar aspect. Our study yielded promising results, successfully reconstructing and meticulously describing the anatomy of nerve fibers spanning from the carpus to the digital nerve division, alongside the identification of Pacinian corpuscles, in four healthy volunteers (eight hands).
摘要：
7T临床MRI技术的出现激发了我们对其辨别手部复杂结构的能力的兴趣。我们的主要目的是评估手的感觉和运动神经结构，特别是神经和Pacinian小体，具有帮助诊断工作和支持重建外科手术的双重目的。获得伦理批准对一组志愿者进行7TMRI扫描。四名志愿者采取俯卧姿势，他们的手(N=8)处于“超人”的姿势。将手固定并保持在严格的水平位置,它被贴在塑料板上。实施了被动B0匀场。一旦使用多发射头线圈获得高分辨率3D图像，先进的后处理技术被用来精心描绘神经纤维网络和机械感受器。在所有参与者中，数字神经始终位于指骨区域，平均而言,皮下2.5至3.5毫米，除了在神经距离表面约1.8毫米的屈曲褶皱内。在指骨区域，指状神经到关节的平均距离约为1.5mm.手指的神经比皮肤表面更靠近骨骼。此外，Pacinian小体主要在掌骨区内表现出明显的聚集，位于掌面。我们的研究取得了有希望的结果，成功地重建和细致地描述了从腕骨到数字神经分裂的神经纤维的解剖结构，除了对太平洋小体的鉴定，在四个健康的志愿者（八手）。
