PDF(Pubmed)
Abstract：
Ischemic stroke is a significant public health concern, with its incidence expected to double over the next 40 years, particularly among individuals over 75 years old. Previous studies, such as the DAWN trial, have highlighted the importance of correlating clinical severity with ischemic stroke volume to optimize patient management. Our study aimed to correlate the clinical severity of ischemic stroke, as assessed by the NIHSS score, with ischemic stroke volume measured using DWI, and short-term prognosis quantified by the mRS score at discharge. Conducted at the largest hospital in Gorj County from January 2023 to December 2023, this study enrolled 43 consecutive patients with acute ischemic stroke. In our patient cohort, we observed a strong positive correlation between NIHSS score and ischemic stroke volume (Spearman correlation coefficient = 0.982, p < 0.01), and a strong negative correlation between ASPECTS-DWI score and mRS score (Spearman correlation coefficient = -0.952, p < 0.01). Multiple linear regression analysis revealed a significant collective relationship between ASPECTS score, ischemic stroke volume, and NIHSS score (F(1, 41) = 600.28, p < 0.001, R2 = 0.94, R2adj = 0.93). These findings underscore the importance of DWI in assessing ischemic stroke severity and prognosis, warranting further investigation for its integration into clinical practice.
摘要：
缺血性中风是一个重要的公共卫生问题，它的发病率预计将在未来40年内翻一番，尤其是75岁以上的人。以前的研究，比如DAWN的审判,强调了将临床严重程度与缺血性卒中量相关联以优化患者管理的重要性。我们的研究旨在关联缺血性卒中的临床严重程度，根据NIHSS评分评估，使用DWI测量缺血性中风量，和出院时mRS评分量化的短期预后。这项研究于2023年1月至2023年12月在Gorj县最大的医院进行，连续招募了43名急性缺血性中风患者。在我们的患者队列中，我们观察到NIHSS评分与缺血性卒中量之间存在很强的正相关（Spearman相关系数=0.982，p<0.01），ASPECTS-DWI评分与mRS评分呈强负相关(Spearman相关系数=-0.952,p<0.01)。多元线性回归分析显示ASPECTS评分之间存在显著的集体关系，缺血性卒中体积,NIHSS评分(F(1,41)=600.28,p<0.001,R2=0.94,R2adj=0.93)。这些发现强调了DWI在评估缺血性卒中严重程度和预后中的重要性。需要进一步研究，以将其融入临床实践。
