PDF(Pubmed)
Abstract：
Depression is the most common mental disorder worldwide. Both antidepressants and psychotherapy are effective in treating depression, but the response to these treatments is often incomplete. Yoga-based interventions (YBIs) have been advocated by some researchers as a promising form of alternative treatment for depression. Recent research has attempted to identify the biological mechanisms associated with the antidepressant actions of YBIs. In this scoping review, conducted according to the PRISMA-ScR guidelines, the PubMed and Scopus databases were searched to retrieve research on biomarkers of response to YBIs in patients with depression. These studies were also critically reviewed to evaluate their methodological quality and any sources of bias. Nineteen studies were included in the review. Based on these studies, there is preliminary evidence that YBIs may be associated with increased serum brain-derived neurotrophic factor (BDNF) and reduced serum cortisol and interleukin-6 (IL-6) in patients with depression. However, many of these changes were also observed in the control arms, and the overall quality of the research was low. At present, it cannot be concluded that there are reliable biomarkers of response to YBIs in depression, though there are some potential biological correlates. Further advances in this field will depend critically on improvements in study design, particularly the minimization of sources of bias and the selection of more specific and sensitive biomarkers based on existing evidence from other treatment modalities.
摘要：
抑郁症是全世界最常见的精神障碍。抗抑郁药和心理治疗都能有效治疗抑郁症,但是对这些治疗的反应通常是不完全的。一些研究人员提倡以瑜伽为基础的干预措施（YBI）作为抑郁症的替代治疗方法。最近的研究试图确定与YBI的抗抑郁作用相关的生物学机制。在这次范围审查中，根据PRISMA-ScR指南进行，本研究检索了PubMed和Scopus数据库,以检索有关抑郁症患者对YBI应答的生物标志物的研究.还对这些研究进行了严格审查，以评估其方法学质量和任何偏倚来源。19项研究纳入审查。基于这些研究,有初步证据表明，YBI可能与抑郁症患者血清脑源性神经营养因子（BDNF）升高，血清皮质醇和白细胞介素-6（IL-6）降低有关。然而,其中许多变化也在控制武器中观察到，研究总体质量较低。目前,不能断定抑郁症患者对YBI的反应有可靠的生物标志物，尽管有一些潜在的生物关联。这一领域的进一步进展将关键取决于研究设计的改进，特别是根据其他治疗方式的现有证据，最大限度地减少偏倚来源，并选择更特异和更敏感的生物标志物。
