PDF(Pubmed)
Abstract：
Wound healing involves physical, chemical and immunological processes. Transient receptor potential (TRP) and other ion channels are implicated in epidermal re-epithelization. Ion movement across ion channels can induce transmembrane potential that leads to transepithelial potential (TEP) changes. TEP is present in epidermis surrounding the lesion decreases and induces an endogenous direct current generating an epithelial electric field (EF) that could be implicated in wound re-epithelialization. TRP channels are involved in the activation of immune cells during mainly the inflammatory phase of wound healing. The aim of the study was to review the mechanisms of ion channel involvement in wound healing in in vivo experiments in murine (mice, rats) and how can this process be influenced. This review used the latest results published in scientific journals over the last year and this year to date (1 January 2023-31 December 3000) in order to include the in-press articles. Some types of TRP channels, such as TRPV1, TRPV3 and TRPA1, are expressed in immune cells and can be activated by inflammatory mediators. The most beneficial effects in wound healing are produced using agonists of TRPV1, TRPV4 and TRPA1 channels or by inhibiting with antagonists, antisense oligonucleotides or knocking down TRPV3 and TRPM8 channels.
摘要：
伤口愈合涉及身体，化学和免疫过程。瞬时受体电位（TRP）和其他离子通道与表皮再上皮化有关。跨离子通道的离子运动可以诱导跨膜电位，从而导致跨上皮电位（TEP）变化。TEP存在于病变周围的表皮中，减少并诱导内源性直流电产生上皮电场（EF），这可能与伤口上皮再形成有关。TRP通道主要在伤口愈合的炎症阶段参与免疫细胞的激活。该研究的目的是在小鼠体内实验中回顾离子通道参与伤口愈合的机制（小鼠，大鼠)以及如何影响这一过程。这篇评论使用了过去一年和今年迄今为止（2023年1月1日至12月31日3000）在科学期刊上发表的最新结果，以包括新闻中的文章。某些类型的TRP频道，如TRPV1、TRPV3和TRPA1，在免疫细胞中表达，并可被炎症介质激活。使用TRPV1，TRPV4和TRPA1通道的激动剂或通过用拮抗剂抑制，反义寡核苷酸或敲低TRPV3和TRPM8通道。
