PDF(Pubmed)
Abstract：
Krause\'s corpuscles are typical of cutaneous mucous epithelia, like the lip vermillion or the glans clitoridis, and are associated with rapidly adapting low-threshold mechanoreceptors involved in gentle touch or vibration. PIEZO1 and PIEZO2 are transmembrane mechano-gated proteins that form a part of the cationic ion channels required for mechanosensitivity in mammalian cells. They are involved in somatosensitivity, especially in the different qualities of touch, but also in pain and proprioception. In the present study, immunohistochemistry and immunofluorescence were used to analyze the occurrence and cellular location of PIEZO1 and PIEZO2 in human clitoral Krause\'s corpuscles. Both PIEZO1 and PIEZO2 were detected in Krause\'s corpuscles in both the axon and the terminal glial cells. The presence of PIEZOs in the terminal glial cells of Kraus\'s corpuscles is reported here for the first time. Based on the distribution of PIEZO1 and PIEZO2, it may be assumed they could be involved in mechanical stimuli, sexual behavior, and sexual pleasure.
摘要：
Krause的小体是典型的皮肤粘液上皮，像唇瓣或阴蒂，并且与快速适应参与轻柔触摸或振动的低阈值机械感受器有关。PIEZO1和PIEZO2是跨膜机械门控蛋白,其形成哺乳动物细胞中机械敏感性所需的阳离子离子通道的一部分。他们参与了躯体敏感性，尤其是在不同的触摸品质中，还有疼痛和本体感受。在本研究中,采用免疫组织化学和免疫荧光分析人阴蒂Krause小体中PIEZO1和PIEZO2的发生和细胞定位。在轴突和末端神经胶质细胞的Krause小体中均检测到PIEZO1和PIEZO2。本文首次报道了克劳斯小体末端神经胶质细胞中PIEZOs的存在。根据PIEZO1和PIEZO2的分布，可以假设它们可能参与机械刺激，性行为,和性快感。
