PDF(Pubmed)
Abstract：
Despite the recognized potential of nanoparticles, only a few formulations have progressed to clinical trials, and an even smaller number have been approved by the regulatory authorities and marketed. Virus-like particles (VLPs) have emerged as promising alternatives to conventional nanoparticles due to their safety, biocompatibility, immunogenicity, structural stability, scalability, and versatility. Furthermore, VLPs can be surface-functionalized with small molecules to improve circulation half-life and target specificity. Through the functionalization and coating of VLPs, it is possible to optimize the response properties to a given stimulus, such as heat, pH, an alternating magnetic field, or even enzymes. Surface functionalization can also modulate other properties, such as biocompatibility, stability, and specificity, deeming VLPs as potential vaccine candidates or delivery systems. This review aims to address the different types of surface functionalization of VLPs, highlighting the more recent cutting-edge technologies that have been explored for the design of tailored VLPs, their importance, and their consequent applicability in the medical field.
摘要：
尽管纳米粒子具有公认的潜力，只有少数配方已经进入临床试验，监管机构批准并上市的数量更少。病毒样颗粒（VLP）由于其安全性而成为传统纳米颗粒的有希望的替代品，生物相容性，免疫原性,结构稳定性,可扩展性，和多功能性。此外，VLP可用小分子进行表面官能化,以改善循环半衰期和靶标特异性。通过VLP的功能化和涂覆，可以优化对给定刺激的响应特性，比如热，pH值,交变磁场,甚至酶。表面功能化还可以调节其他性质，如生物相容性，稳定性,和特异性，将VLP视为潜在的疫苗候选物或递送系统。这篇综述旨在解决VLP的不同类型的表面功能化，重点介绍了为设计量身定制的VLP而探索的最新尖端技术，其重要性,以及它们在医学领域的适用性。
