PDF(Pubmed)
Abstract：
Five new diterpenes including four diterpenes with 1,2,3,4,4a,5,6,8a-octalin skeleton talaroacids A-D (1-4) and an isopimarane diterpenoid talaromarane A (5) were isolated from the mangrove endophytic fungus Talaromyces sp. JNQQJ-4. Their structures and absolute configurations were determined by analysis of high-resolution electrospray ionization mass spectroscopy (HRESIMS), 1D/2D Nuclear Magnetic Resonance (NMR) spectra, single-crystal X-ray diffraction, quantum chemical calculation, and electronic circular dichroism (ECD). Talaromarane A (5) contains a rare 2-oxabicyclo [3.2.1] octan moiety in isopimarane diterpenoids. In bioassays, compounds 1, 2, 4, and 5 displayed significant anti-inflammatory activities with the IC50 value from 4.59 to 21.60 μM.
摘要：
五个新的二萜，包括四个二萜和1,2,3,4,4a，从红树林内生真菌Talaromycessp。中分离出5,6,8a-octalin骨架滑石酸A-D（1-4）和异imarane二萜滑石A（5）。JNQQJ-4.通过高分辨率电喷雾电离质谱（HRESIMS）分析确定了它们的结构和绝对构型，1D/2D核磁共振（NMR）光谱，单晶X射线衍射,量子化学计算,和电子圆二色性（ECD）。TalaramaraneA（5）在异imarane二萜中含有稀有的2-氧杂双环[3.2.1]octan部分。在生物测定中，化合物1、2、4和5显示出显著的抗炎活性,IC50值为4.59至21.60μM。
