PDF(Pubmed)
Abstract：
Graphene, when electrified, generates far-infrared radiation within the wavelength range of 4 μm to 14 μm. This range closely aligns with the far-infrared band (3 μm to 15 μm), which produces unique physiological effects. Contraction and relaxation of vascular smooth muscle play a significant role in primary hypertension, involving the nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate pathway and the renin-angiotensin-aldosterone system. This study utilized spontaneously hypertensive rats (SHRs) as an untr-HT to investigate the impact of far-infrared radiation at specific wavelengths generated by electrified graphene on vascular smooth muscle and blood pressure. After 7 weeks, the blood pressure of the untr-HT group rats decreased significantly with a notable reduction in the number of vascular wall cells and the thickness of the vascular wall, as well as a decreased ratio of vessel wall thickness to lumen diameter. Additionally, blood flow perfusion significantly increased, and the expression of F-actin in vascular smooth muscle myosin decreased significantly. Serum levels of angiotensin II (Ang-II) and endothelin 1 (ET-1) were significantly reduced, while nitric oxide synthase (eNOS) expression increased significantly. At the protein level, eNOS expression decreased significantly, while α-SMA expression increased significantly in aortic tissue. At the gene level, expressions of eNOS and α-SMA in aortic tissue significantly increased. Furthermore, the content of nitric oxide (NO) in the SHR\'s aortic tissue increased significantly. These findings confirm that graphene far-infrared radiation enhances microcirculation, regulates cytokines affecting vascular smooth muscle contraction, and modifies vascular morphology and smooth muscle phenotype, offering relief for primary hypertension.
摘要：
石墨烯,通电时,产生波长范围为4μm至14μm的远红外辐射。该范围与远红外波段（3μm至15μm）紧密对齐，产生独特的生理效应。血管平滑肌的收缩和松弛在原发性高血压中起着重要作用，涉及一氧化氮可溶性鸟苷酸环化酶-环磷酸鸟苷途径和肾素-血管紧张素-醛固酮系统。这项研究利用自发性高血压大鼠（SHR）作为untr-HT来研究由带电石墨烯产生的特定波长的远红外辐射对血管平滑肌和血压的影响。7周后,untr-HT组大鼠血压明显下降，血管壁细胞数量和血管壁厚度明显减少，以及血管壁厚度与管腔直径的比率降低。此外,血流灌注明显增加,血管平滑肌肌球蛋白中F-actin的表达明显降低。血清血管紧张素Ⅱ(Ang-Ⅱ)和内皮素1(ET-1)水平显著降低,而一氧化氮合酶（eNOS）表达显著增加。在蛋白质水平，eNOS表达显著下降,而α-SMA在主动脉组织中的表达明显增加。在基因层面,主动脉组织中eNOS和α-SMA的表达明显增加。此外，SHR主动脉组织中一氧化氮(NO)含量显著升高。这些发现证实了石墨烯远红外辐射增强了微循环，调节影响血管平滑肌收缩的细胞因子，并改变血管形态和平滑肌表型，为原发性高血压提供救济。
