PDF(Pubmed)
Abstract：
Lung cancer has an unfavorable prognosis with a rate of low overall survival, caused by the difficulty of diagnosis in the early stages and resistance to therapy. In recent years, there have been new therapies that use specific molecular targets and are effective in increasing the survival chances of advanced cancer. Therefore, it is necessary to find more specific biomarkers that can identify early changes in carcinogenesis and allow the earliest possible treatment. Vitamin D (VD) plays an important role in immunity and carcinogenesis. Furthermore, the vitamin D receptor (VDR) regulates the expression of various genes involved in the physiological functions of the human organism. The genes encoding the VDR are extremely polymorphic and vary greatly between human populations. To date, there are significant associations between VDR polymorphism and several types of cancer, but the data on the involvement of VDR polymorphism in lung cancer are still conflicting. Therefore, in this review, our aim was to investigate the relationship between VDR single-nucleotide polymorphisms in humans and the degree of risk for developing lung cancer. The studies showcased different gene polymorphisms to be associated with an increased risk of lung cancer: TaqI, ApaI, BsmI, FokI, and Cdx2. In addition, there is a strong positive correlation between VD deficiency and lung cancer development. Still, due to a lack of awareness, the assessment of VD status and VDR polymorphism is rarely considered for the prediction of lung cancer evolution and their clinical applicability, despite the fact that studies have shown the highest risk for lung cancer given by TaqI gene polymorphisms and that VDR polymorphisms are associated with more aggressive cancer evolution.
摘要：
肺癌预后不良，总生存率低，由早期诊断困难和对治疗的抵抗引起的。近年来,已经有新的疗法，使用特定的分子靶标，并有效地增加晚期癌症的生存机会。因此,有必要找到更具体的生物标志物，以识别癌变的早期变化，并允许尽早治疗。维生素D（VD）在免疫和致癌作用中起重要作用。此外，维生素D受体（VDR）调节与人体生理功能有关的各种基因的表达。编码VDR的基因是极其多态的,并且在人群之间差异很大。迄今为止,VDR多态性与几种癌症之间存在显著关联，但是关于VDR多态性与肺癌的关系的数据仍然相互矛盾。因此,在这次审查中,我们的目的是研究人类VDR单核苷酸多态性与肺癌发病风险之间的关系.研究表明，不同的基因多态性与肺癌风险增加有关：TaqI，ApaI,Bsmi,FokI,Cdx2此外,VD缺乏与肺癌的发生发展有很强的正相关性。尽管如此，由于缺乏意识，VD状态和VDR多态性的评估很少被考虑用于预测肺癌的演变及其临床适用性，尽管研究表明TaqI基因多态性导致肺癌的风险最高，并且VDR多态性与更具侵袭性的癌症进化相关。
