PDF(Pubmed)
Abstract：
Migraine is a common and debilitating neurological disorder characterized by the recurrent attack of pulsating headaches typically localized on one side of the head associated with other disabling symptoms, such as nausea, increased sensitivity to light, sound and smell and mood changes. Various clinical factors, including the excessive use of migraine medication, inadequate acute treatment and stressful events, can contribute to the worsening of the condition, which may evolve to chronic migraine, that is, a headache present on >15 days/month for at least 3 months. Chronic migraine is frequently associated with various comorbidities, including anxiety and mood disorders, particularly depression, which complicate the prognosis, response to treatment and overall clinical outcomes. Emerging research indicates a connection between alterations in the composition of the gut microbiota and mental health conditions, particularly anxiety and depression, which are considered disorders of the gut-brain axis. This underscores the potential of modulating the gut microbiota as a new avenue for managing these conditions. In this context, it is interesting to investigate whether migraine, particularly in its chronic form, exhibits a dysbiosis profile similar to that observed in individuals with anxiety and depression. This could pave the way for interventions aimed at modulating the gut microbiota for treating difficult-to-manage migraines.
摘要：
偏头痛是一种常见且使人衰弱的神经系统疾病，其特征是脉动性头痛的反复发作，通常位于头部的一侧，并伴有其他致残症状。比如恶心，增加对光的敏感度，声音、气味和情绪变化。各种临床因素，包括过度使用偏头痛药物，不充分的急性治疗和应激事件，会导致病情恶化，可能演变成慢性偏头痛，也就是说,头痛出现>15天/月至少3个月。慢性偏头痛通常与各种合并症有关，包括焦虑和情绪障碍，尤其是抑郁症,使预后复杂化，对治疗的反应和总体临床结果。新兴研究表明，肠道微生物群组成的改变与心理健康状况之间存在联系，尤其是焦虑和抑郁，这被认为是肠-脑轴的疾病。这强调了调节肠道微生物群作为管理这些疾病的新途径的潜力。在这种情况下，调查偏头痛是否有趣，特别是其慢性形式，表现出与焦虑和抑郁个体相似的生态失调特征。这可能为旨在调节肠道微生物群治疗难以控制的偏头痛的干预措施铺平道路。
