PDF(Pubmed)
Abstract：
Pericytes are multipotent cells embedded within the vascular system, primarily surrounding capillaries and microvessels where they closely interact with endothelial cells. These cells are known for their intriguing properties due to their heterogeneity in tissue distribution, origin, and multifunctional capabilities. Specifically, pericytes are essential in regulating blood flow, promoting angiogenesis, and supporting tissue homeostasis and regeneration. These multifaceted roles draw on pericytes\' remarkable ability to respond to biochemical cues, interact with neighboring cells, and adapt to changing environmental conditions. This review aims to summarize existing knowledge on pericytes, emphasizing their versatility and involvement in vascular integrity and tissue health. In particular, a comprehensive view of the major signaling pathways, such as PDGFβ/ PDGFRβ, TGF-β, FOXO and VEGF, along with their downstream targets, which coordinate the behavior of pericytes in preserving vascular integrity and promoting tissue regeneration, will be discussed. In this light, a deeper understanding of the complex signaling networks defining the phenotype of pericytes in healthy tissues is crucial for the development of targeted therapies in vascular and degenerative diseases.
摘要：
周细胞是嵌入血管系统的多能细胞,主要围绕毛细血管和微血管，它们与内皮细胞紧密相互作用。这些细胞因其组织分布的异质性而以其有趣的特性而闻名。origin,和多功能能力。具体来说,周细胞对调节血流至关重要，促进血管生成，并支持组织稳态和再生。这些多方面的作用依赖于周细胞对生化线索做出反应的非凡能力，与相邻细胞相互作用，适应不断变化的环境条件。这篇综述旨在总结有关周细胞的现有知识，强调它们的多功能性和参与血管完整性和组织健康。特别是,对主要信号通路的全面看法，如PDGFβ/PDGFRβ，TGF-β,FOXO和VEGF,以及它们的下游目标，协调周细胞在保持血管完整性和促进组织再生方面的行为，将讨论。在这种情况下，更深入地了解定义健康组织周细胞表型的复杂信号网络对于血管和退行性疾病靶向治疗的发展至关重要.
