PDF(Pubmed)
Abstract：
Atopic dermatitis (AD) is a chronic inflammatory skin condition with a high prevalence worldwide. AD pathogenesis is complex and consists of immune system dysregulation and impaired skin barrier, influenced by genetic and environmental factors. The purpose of the review is to show the complex interplay between atopic dermatitis and the microbiota. Human microbiota plays an important role in AD pathogenesis and the course of the disease. Dysbiosis is an important factor contributing to the development of atopic diseases, including atopic dermatitis. The gut microbiota can influence the composition of the skin microbiota, strengthening the skin barrier and regulating the immune response via the involvement of bacterial metabolites, particularly short-chain fatty acids, in signaling pathways of the gut-skin axis. AD can be modulated by antibiotic intake, dietary adjustments, hygiene, and living conditions. One of the promising strategies for modulating the course of AD is probiotics. This review offers a summary of how the microbiota influences the development and treatment of AD, highlighting aspects that warrant additional investigation.
摘要：
特应性皮炎（AD）是一种慢性炎症性皮肤病，在全球范围内患病率很高。AD发病机制复杂，包括免疫系统失调和皮肤屏障受损，受遗传和环境因素的影响。该综述的目的是显示特应性皮炎与微生物群之间的复杂相互作用。人类微生物群在AD的发病机制和病程中起着重要作用。菌群失调是导致特应性疾病发展的重要因素，包括特应性皮炎.肠道微生物群可以影响皮肤微生物群的组成，通过细菌代谢物的参与加强皮肤屏障和调节免疫反应，特别是短链脂肪酸，在肠-皮肤轴的信号通路中。AD可以通过抗生素的摄入来调节，饮食调整，卫生,和生活条件。调节AD病程的有希望的策略之一是益生菌。这篇综述总结了微生物群如何影响AD的发展和治疗。强调需要进一步调查的方面。
