PDF(Pubmed)
Abstract：
Endometriosis (EM), a chronic condition in endometrial tissue outside the uterus, affects around 10% of reproductive-age women, significantly affecting fertility. Its prevalence remains elusive due to the surgical confirmation needed for diagnosis. Manifesting with a range of symptoms, including dysmenorrhea, dyschezia, dysuria, dyspareunia, fatigue, and gastrointestinal discomfort, EM significantly impairs quality of life due to severe chronic pelvic pain (CPP). Psychological manifestations, notably depression and anxiety, frequently accompany the physical symptoms, with CPP serving as a key mediator. Pain stems from endometrial lesions, involving oxidative stress, neuroinflammation, angiogenesis, and sensitization processes. Microbial dysbiosis appears to be crucial in the inflammatory mechanisms underlying EM and associated CPP, as well as psychological symptoms. In this scenario, dietary interventions and nutritional supplements could help manage EM symptoms by targeting inflammation, oxidative stress, and the microbiome. Our manuscript starts by delving into the complex relationship between EM pain and psychological comorbidities. It subsequently addresses the emerging roles of the microbiome, inflammation, and oxidative stress as common links among these abovementioned conditions. Furthermore, the review explores how dietary and nutritional interventions may influence the composition and function of the microbiome, reduce inflammation and oxidative stress, alleviate pain, and potentially affect EM-associated psychological disorders.
摘要：
子宫内膜异位症(EM),子宫外子宫内膜组织的慢性疾病,影响了大约10%的育龄妇女，显著影响生育能力。由于诊断需要手术确认，其患病率仍然难以捉摸。表现出一系列的症状,包括痛经,Dyschezia,排尿困难,性交困难,疲劳,肠胃不适,由于严重的慢性盆腔疼痛（CPP），EM会严重损害生活质量。心理表现,尤其是抑郁和焦虑，经常伴随身体症状，CPP充当关键调解人。疼痛源于子宫内膜病变，涉及氧化应激，神经炎症，血管生成,和敏化过程。微生物菌群失调似乎在EM和相关CPP的炎症机制中至关重要，以及心理症状。在这种情况下，饮食干预和营养补充剂可以通过针对炎症来帮助控制EM症状，氧化应激，和微生物组。我们的手稿首先深入研究了EM疼痛与心理合并症之间的复杂关系。它随后解决了微生物组的新兴作用，炎症,和氧化应激作为上述条件之间的常见联系。此外，这篇综述探讨了饮食和营养干预如何影响微生物组的组成和功能，减少炎症和氧化应激，缓解疼痛,并可能影响EM相关的心理障碍。
