PDF(Pubmed)
Abstract：
Valvular disease is a complex pathological condition that impacts countless individuals around the globe. Due to limited treatments, it is crucial to understand its mechanisms to identify new targets. Valve disease may result in pulmonary venous hypertension, which is linked to compromised functioning of the alveolar and capillary membranes and hindered gas exchange. Nonetheless, the correlation between surfactant proteins (SPs) and valve disease remains unexplored. A total of 44 patients were enrolled in this study, with 36 undergoing aortic valve replacement and 8 needing a second aortic valve substitution due to bioprosthetic valve degeneration. Ten healthy subjects were also included. The results showed that patients who underwent both the first valve replacement and the second surgery had significantly higher levels of immature SP-B (proSP-B) compared to control subjects. The levels of the extra-lung collectin SP-D were higher in patients who needed a second surgery due to bioprosthetic valve degeneration, while SP-A levels remained unchanged. The research also showed that there was no reciprocal relationship between inflammation and SP-D as the levels of inflammatory mediators did not differ between groups. The present study demonstrates that circulating proSP-B serves as a reliable marker of alveolar-capillary membrane damage in patients with valvular heart disease.
摘要：
瓣膜疾病是一种复杂的病理状况，影响着全球无数的个体。由于有限的治疗，了解其确定新目标的机制至关重要。瓣膜疾病可能导致肺静脉高压，这与肺泡和毛细管膜的功能受损有关，并阻碍了气体交换。尽管如此，表面活性蛋白(SPs)与瓣膜疾病之间的相关性仍未被研究.本研究共纳入44例患者，36例接受主动脉瓣置换术，8例由于生物瓣膜退化而需要第二次主动脉瓣置换术。还包括10名健康受试者。结果表明，与对照组相比，同时接受第一次瓣膜置换和第二次手术的患者的未成熟SP-B（proSP-B）水平明显更高。由于生物瓣膜变性而需要第二次手术的患者，肺外聚集素SP-D的水平较高，而SP-A水平保持不变。研究还表明，炎症和SP-D之间没有相互关系，因为炎症介质的水平在组间没有差异。本研究表明，循环proSP-B可作为瓣膜性心脏病患者肺泡毛细血管膜损伤的可靠标志物。
