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Abstract：
Endometrial cancer (EC) is one of the most common malignant tumors among women in the 21st century, whose mortality rate is increasing every year. Currently, the diagnosis of EC is possible only after a biopsy. However, it is necessary to find a new biomarker that will help in both the diagnosis and treatment of EC in a non-invasive way. Circular RNAs (circRNAs) are small, covalently closed spherical and stable long non-coding RNAs (lncRNAs) molecules, which are abundant in both body fluids and human tissues and are expressed in various ways. Considering the new molecular classification of EC, many studies have appeared, describing new insights into the functions and mechanisms of circRNAs in EC. In this review article, we focused on the problem of EC and the molecular aspects of its division, as well as the biogenesis, functions, and diagnostic and clinical significance of circRNAs in EC.
摘要：
子宫内膜癌是21世纪女性最常见的恶性肿瘤之一。其死亡率每年都在增加。目前,只有在活检后才有可能诊断为EC.然而,有必要寻找一种新的生物标志物，以有助于非侵入性的方式诊断和治疗EC。环状RNA（circularRNAs）很小，共价闭合球形和稳定的长非编码RNA（lncRNAs）分子，它们在体液和人体组织中都很丰富，并以各种方式表达。考虑到EC的新分子分类，许多研究已经出现，描述对EC中circRNAs的功能和机制的新见解。在这篇评论文章中，我们专注于EC的问题及其划分的分子方面，以及生物发生，功能,以及circRNAs在EC中的诊断和临床意义。
