PDF(Pubmed)
Abstract：
Since transcription factor Forkhead Box P3 (FoxP3) was identified as a specific regulatory T cell (Treg) marker, researchers have scrutinized its value as a potential novel therapeutic target or a prognostic factor in various types of cancer with inconsistent results. The present analysis was performed to assess the influence of Treg FoxP3 expression on the prognosis of primary melanoma and to evaluate the correlations with various clinicopathological prognostic factors. We analyzed all eligible patients with stage pT3 primary malignant melanomas treated in a tertiary cancer center. Immunohistochemical staining for Treg FoxP3 expression was performed on retrospectively identified paraffin blocks and subsequently correlated with the outcomes of the patients. A total of 81% of the patients presented a positive Treg FoxP3 expression, being correlated with a higher risk of lymph node metastasis, tumor relapse, and death. Moreover, positive expression was statistically associated with a shorter OS. The tumor relapse rate was estimated at 36.7%. A positive expression of Treg FoxP3 and lymph node metastasis were associated with a higher risk of death based on multivariate analysis. Treg FoxP3 expression may be used as an independent prognostic factor in patients with malignant melanoma to evaluate tumor progression and survival.
摘要：
由于转录因子ForkheadBoxP3（FoxP3）被鉴定为特异性调节性T细胞（Treg）标记，研究人员已经仔细研究了其作为潜在的新型治疗靶点或不同类型癌症预后因素的价值,但结果不一致.本分析旨在评估TregFoxP3表达对原发性黑色素瘤预后的影响，并评估其与各种临床病理预后因素的相关性。我们分析了在三级癌症中心治疗的所有合格的pT3期原发性恶性黑色素瘤患者。对回顾性鉴定的石蜡块进行TregFoxP3表达的免疫组织化学染色，随后与患者的预后相关。总共81%的患者呈现阳性TregFoxP3表达,与更高的淋巴结转移风险相关，肿瘤复发，和死亡。此外，阳性表达在统计学上与较短的OS相关。肿瘤复发率估计为36.7%。多因素分析显示，TregFoxP3阳性表达和淋巴结转移与较高的死亡风险相关。TregFoxP3的表达可作为评价恶性黑色素瘤患者肿瘤进展和生存的独立预后因子。
