PDF(Pubmed)
Abstract：
Worldwide, osteoarthritis (OA) is the most common cause of joint pain in older people. Many factors contribute to osteoarthritis\' development and progression, including secondary osteoarthritis\' underlying causes. It is important to note that osteoarthritis affects all four tissues: cartilage, bone, joint capsule, and articular apparatus. An increasingly prominent area of research in osteoarthritis regulation is microRNAs (miRNAs), a small, single-stranded RNA molecule that controls gene expression in eukaryotes. We aimed to assess and summarize current knowledge about the mechanisms of the action of miRNAs and their clinical significance. Osteoarthritis (OA) is affected by the interaction between miRNAs and inflammatory processes, as well as cartilage metabolism. MiRNAs also influence cartilage cell apoptosis, contributing to the degradation of the cartilage in OA. Studies have shown that miRNAs may have both an inhibitory and promoting effect on osteoporosis progression through their influence on molecular mechanisms. By identifying these regulators, targeted treatments for osteoarthritis may be developed. In addition, microRNA may also serve as a biomarker for osteoarthritis. By using these biomarkers, the disease could be detected faster, and early intervention can be instituted to prevent mobility loss and slow deterioration.
摘要：
全球,骨关节炎（OA）是老年人关节疼痛的最常见原因。许多因素有助于骨关节炎的发展和进展，包括继发性骨关节炎的根本原因。重要的是要注意，骨关节炎影响所有四种组织：软骨，骨头,关节囊,和关节装置。骨关节炎调控的一个日益突出的研究领域是microRNAs(miRNAs),一个小,在真核生物中控制基因表达的单链RNA分子。我们旨在评估和总结有关miRNA作用机制及其临床意义的最新知识。骨关节炎（OA）受到miRNAs和炎症过程之间相互作用的影响，以及软骨代谢。miRNA还影响软骨细胞凋亡，有助于OA中软骨的降解。研究表明，miRNA可能通过影响其分子机制对骨质疏松症的进展具有抑制作用和促进作用。通过识别这些监管机构，可以开发针对骨关节炎的靶向治疗。此外,microRNA也可以作为骨关节炎的生物标志物。通过使用这些生物标志物，这种疾病可以更快地检测到，可以采取早期干预措施，以防止行动不便和缓慢恶化。
